Recombinant human MAP4K1/HPK1 protein (Active) is a Human Full Length protein, in the 1 to 833 aa range, expressed in Baculovirus infected Sf9, with >70% purity and suitable for SDS-PAGE, FuncS.
>70% SDS-PAGE
Baculovirus infected Sf9 cells
GST tag N-Terminus
SDS-PAGE, FuncS
Yes
M D V V D P D I F N R D P R D H Y D L L Q R L G G G T Y G E V F K A R D K V S G D L V A L K M V K M E P D D D V S T L Q K E I L I L K T C R H A N I V A Y H G S Y L W L Q K L W I C M E F C G A G S L Q D I Y Q V T G S L S E L Q I S Y V C R E V L Q G L A Y L H S Q K K I H R D I K G A N I L I N D A G E V R L A D F G I S A Q I G A T L A R R L S F I G T P Y W M A P E V A A V A L K G G Y N E L C D I W S L G I T A I E L A E L Q P P L F D V H P L R V L F L M T K S G Y Q P P R L K E K G K W S A A F H N F I K V T L T K S P K K R P S A T K M L S H Q L V S Q P G L N R G L I L D L L D K L K N P G K G P S I G D I E D E E P E L P P A I P R R I R S T H R S S S L G I P D A D C C R R H M E F R K L R G M E T R P P A N T A R L Q P P R D L R S S S P R K Q L S E S S D D D Y D D V D I P T P A E D T P P P L P P K P K F R S P S D E G P G S M G D D G Q L S P G V L V R C A S G P P P N S P R P G P P P S T S S P H L T A H S E P S L W N P P S R E L D K P P L L P P K K E K M K R K G C A L L V K L F N G C P L R I H S T A A W T H P S T K D Q H L L L G A E E G I F I L N R N D Q E A T L E M L F P S R T T W V Y S I N N V L M S L S G K T P H L Y S H S I L G L L E R K E T R A G N P I A H I S P H R L L A R K N M V S T K I Q D T K G C R A C C V A E G A S S G G P F L C G A L E T S V V L L Q W Y Q P M N K F L L V R Q V L F P L P T P L S V F A L L T G P G S E L P A V C I G V S P G R P G K S V L F H T V R F G A L S C W L G E M S T E H R G P V Q V T Q V E E D M V M V L M D G S V K L V T P E G S P V R G L R T P E I P M T E A V E A V A M V G G Q L Q A F W K H G V Q V W A L G S D Q L L Q E L R D P T L T F R L L G S P R L E C S G T I S P H C N L L L P G S S N S P A S A S R V A G I T G L
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).
Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, HPK1, MAP4K1
Recombinant human MAP4K1/HPK1 protein (Active) is a Human Full Length protein, in the 1 to 833 aa range, expressed in Baculovirus infected Sf9, with >70% purity and suitable for SDS-PAGE, FuncS.
Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, HPK1, MAP4K1
>70% SDS-PAGE
Baculovirus infected Sf9 cells
GST tag N-Terminus
SDS-PAGE, FuncS
Yes
The specific activity of ab268641 as determined to 54 nmol/min/mg in a kinase assay using MBP substrate.
No
Human
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
M D V V D P D I F N R D P R D H Y D L L Q R L G G G T Y G E V F K A R D K V S G D L V A L K M V K M E P D D D V S T L Q K E I L I L K T C R H A N I V A Y H G S Y L W L Q K L W I C M E F C G A G S L Q D I Y Q V T G S L S E L Q I S Y V C R E V L Q G L A Y L H S Q K K I H R D I K G A N I L I N D A G E V R L A D F G I S A Q I G A T L A R R L S F I G T P Y W M A P E V A A V A L K G G Y N E L C D I W S L G I T A I E L A E L Q P P L F D V H P L R V L F L M T K S G Y Q P P R L K E K G K W S A A F H N F I K V T L T K S P K K R P S A T K M L S H Q L V S Q P G L N R G L I L D L L D K L K N P G K G P S I G D I E D E E P E L P P A I P R R I R S T H R S S S L G I P D A D C C R R H M E F R K L R G M E T R P P A N T A R L Q P P R D L R S S S P R K Q L S E S S D D D Y D D V D I P T P A E D T P P P L P P K P K F R S P S D E G P G S M G D D G Q L S P G V L V R C A S G P P P N S P R P G P P P S T S S P H L T A H S E P S L W N P P S R E L D K P P L L P P K K E K M K R K G C A L L V K L F N G C P L R I H S T A A W T H P S T K D Q H L L L G A E E G I F I L N R N D Q E A T L E M L F P S R T T W V Y S I N N V L M S L S G K T P H L Y S H S I L G L L E R K E T R A G N P I A H I S P H R L L A R K N M V S T K I Q D T K G C R A C C V A E G A S S G G P F L C G A L E T S V V L L Q W Y Q P M N K F L L V R Q V L F P L P T P L S V F A L L T G P G S E L P A V C I G V S P G R P G K S V L F H T V R F G A L S C W L G E M S T E H R G P V Q V T Q V E E D M V M V L M D G S V K L V T P E G S P V R G L R T P E I P M T E A V E A V A M V G G Q L Q A F W K H G V Q V W A L G S D Q L L Q E L R D P T L T F R L L G S P R L E C S G T I S P H C N L L L P G S S N S P A S A S R V A G I T G L
Full Length
1 to 833
Recombinant
GST tag N-Terminus
Liquid
Affinity purified.
Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
Dry Ice
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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Terms & Conditions.
The specific activity of ab268641 as determined to 54 nmol/min/mg in a kinase assay using MBP substrate.
SDS-PAGE analysis of ab268641.
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