Recombinant human MAP4K6 protein
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Recombinant human MAP4K6 protein is a Human Fragment protein, in the 1 to 320 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
View Alternative Names
B55, MAP4K6, MINK, YSK2, ZC3, MINK1, Misshapen-like kinase 1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, Misshapen/NIK-related kinase, Mitogen-activated protein kinase kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6
- FuncS
Unknown
Functional Studies - Recombinant human MAP4K6 protein (AB55712)
The specific activity of MAP4K6 (ab55712) was determined to be 22 nmol/min/mg as per activity assay protocol and was equivalent to 22 nmol/min/mg as per radiometric assay
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human MAP4K6 protein (AB55712)
SDS PAGE analysis of ab55712
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human MAP4K6 protein (AB55712)
SDS-PAGE analysis of ab55712 with molecular weight markers. Approximate molecular weight 61kDa.
- FuncS
Unknown
Functional Studies - Recombinant human MAP4K6 protein (AB55712)
Kinase assay using ab55712. Specific activity : 19 nmol/min/mg.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed : 10708748, PubMed : 16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed : 18930710, PubMed : 21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed : 26437443).. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Post-translational modifications
Autophosphorylated.
Product protocols
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Target data
Product promise
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