Recombinant Human MARCKS like protein

Specifications

Form

Liquid

General info

Function

Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed : 22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Sequence similarities

Belongs to the MARCKS family.

Post-translational modifications

Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin.

Subcellular localisation

Cytoskeleton