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AB158861

Recombinant Human MAS1 protein (GST tag N-Terminus)

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Recombinant Human MAS1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 325 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

MAS, MAS1, Proto-oncogene Mas

1 Images
SDS-PAGE - Recombinant Human MAS1 protein (GST tag N-Terminus) (AB158861)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MAS1 protein (GST tag N-Terminus) (AB158861)

ab158861 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P04201

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB235914

Anti-MAS1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAS1 antibody (AB235914)

  • 0
  • 0
Proteins & Peptides

AB283413

Recombinant Mouse MSTN Protein

Mass Spectrometry - Recombinant Mouse MSTN Protein (AB283413)

  • 0
  • 0
Primary Antibodies

AB215715

Anti-TGF beta 1 antibody [EPR21143]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-TGF beta 1 antibody [EPR21143] (AB215715)

  • 5
  • 6
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

  • 5
  • 105
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":325,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P04201","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAS1 also known as MAS-1 or anti-MAS is a G protein-coupled receptor (GPCR) with a molecular mass of about 37 kDa. It exists in various tissues including the brain heart kidneys and blood vessels. As a receptor MAS1 binds to its ligand to activate intracellular signaling. This receptor's presence in multiple organs highlights its importance in various physiological functions and systems.
Biological function summary

MAS1 functions as a component of the renin-angiotensin system (RAS) where it counteracts the effects often seen with angiotensin II binding to AT1 receptors. It acts as a receptor associated with the signaling of angiotensin-(1-7) a peptide known for vasodilatory and anti-proliferative effects. This receptor is not only a single unit but also participates in forming complexes with other receptor proteins to execute its functions effectively.

Pathways

This receptor engages in the angiotensin-(1-7)/MAS axis a branch of the RAS. This axis balances the actions of the classical angiotensin II/AT1 receptor pathway. Its signaling typically includes pathways involving nitric oxide release and kinases like PI3K and Akt impacting vasodilation and cellular growth inhibition. MAS1 has functional links to proteins like AT1 and AT2 receptors which are also critical components of the RAS.

MAS1 plays a role in conditions like hypertension and heart failure. Its interaction with angiotensin-(1-7) highlights its role in counteracting the CVD-promoting effects of angiotensin II. Moreover in disorders like hypertension MAS1's counter-regulatory function becomes significant highlighting its potential therapeutic value. The target’s modulatory effect on the RAS makes it a relevant protein in cardiovascular research alongside AT1 receptors due to their combined effect on blood pressure regulation and cardiac function.
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Specifications

Form

Liquid

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General info

Function

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels (PubMed : 15809376, PubMed : 16611642). Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade (PubMed : 15809376, PubMed : 16611642). The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (PubMed : 15809376, PubMed : 16611642).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels (PubMed : 15809376, PubMed : 16611642). Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade (PubMed : 15809376, PubMed : 16611642). The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (PubMed : 15809376, PubMed : 16611642).
See full target information MAS1
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