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AB268745

Recombinant Human MAST205 protein (Tagged)

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Recombinant Human MAST205 protein (Tagged) is a Human Fragment protein, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for SDS-PAGE.

View Alternative Names

KIAA0807, MAST205, MAST2, Microtubule-associated serine/threonine-protein kinase 2

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SDS-PAGE - Recombinant Human MAST205 protein (Tagged) (AB268745)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MAST205 protein (Tagged) (AB268745)

SDS-PAGE analysis of ab268745.

Key facts

Purity

>70% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6P0Q8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q6P0Q8","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target MAST205 also referred to as Microtubule-Associated Serine/Threonine Kinase 205 functions mechanically as a kinase that phosphorylates serine and threonine residues on substrate proteins. With a molecular weight of approximately 205 kDa MAST205 plays an important role in signaling pathways. Researchers have found its expression in diverse tissues including brain and heart where it may influence various cellular processes.
Biological function summary

The kinase activity of this protein controls cell division differentiation and signaling. MAST205 often functions as part of a complex that includes other kinases and regulatory proteins influencing microtubule stability and dynamics. This stability is important for proper cell cytoskeleton structure which is essential for accurate cellular functions and movement.

Pathways

The MAST205 kinase joins in cellular mechanisms such as the Wnt and MAPK signaling pathways. These pathways are central to cellular growth development and response to external signals. MAST205 interacts with proteins like GSK3β and MEK1 that help regulate these pathways therefore influencing downstream signaling and physiological responses.

MAST205 connections have been found to cancer and neurodegenerative disorders. In cancer its dysregulation may alter pathways involving proteins such as β-catenin and lead to unchecked cell proliferation. In neurodegenerative disorders the changes in microtubule dynamics and interactions with proteins like tau can result in neural dysfunction and degeneration. Researchers continue to study MAST205 to understand its role in these pathological conditions fully.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Post-translational modifications

Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity).

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).
See full target information MAST2
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