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AB268746

Recombinant human MAST3 protein (Active)

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Recombinant human MAST3 protein (Active) is a Human Fragment protein, in the 1 to 723 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

KIAA0561, MAST3, Microtubule-associated serine/threonine-protein kinase 3

2 Images
Functional Studies - Recombinant human MAST3 protein (Active) (AB268746)
  • FuncS

Supplier Data

Functional Studies - Recombinant human MAST3 protein (Active) (AB268746)

The specific activity was determined to be 3 nmol/min/mg in a kinase assay using full-length recombinant human ARPP19 substrate.

SDS-PAGE - Recombinant human MAST3 protein (Active) (AB268746)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human MAST3 protein (Active) (AB268746)

SDS-PAGE analysis of ab268746.

Key facts

Purity

>90% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

The specific activity was determined to be 3 nmol/min/mg in a kinase assay using full-length recombinant human ARPP19 substrate.

Accession

O60307

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQPTPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERFPKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFLEMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTPTFA","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":723,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"O60307","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MAST3 protein also known as microtubule-associated serine/threonine-protein kinase 3 is a serine/threonine kinase with a molecular mass of approximately 187 kDa. This protein finds expression in various tissues with significant presence in the brain. Functionally MAST3 plays a role in phosphorylation influencing the activity of other proteins through the addition of phosphate groups which is essential for cellular signaling.
Biological function summary

MAST3 protein modulates intracellular signaling pathways by targeting specific substrates involved in neuronal function. This protein is not known to be part of a larger protein complex but interacts with various signaling molecules to execute its functions. In neurons MAST3 influences synaptic plasticity and regulation contributing to proper neuronal communication.

Pathways

MAST3 plays a role in the Wnt signaling pathway which is important for processes like cell proliferation and differentiation. In this pathway MAST3 interacts with proteins such as Dishevelled facilitating discrete phosphorylation events that affect downstream signaling. In addition MAST3 impacts the AKT signaling pathway which is involved in survival and growth of cells by modulating key proteins within the pathway.

MAST3 protein associates with conditions like neurodegenerative diseases and certain types of cancer. In neurodegenerative diseases abnormal MAST3 function can disrupt neuronal signaling contributing to disease progression through altered interactions with tau protein. In cancer aberrant MAST3 expression potentially enhances malignant cell growth and survival by interacting with proteins such as PTEN a well-known tumor suppressor.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

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Product protocols

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Target data

See full target information MAST3
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