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AB78878

Recombinant Human MAT2A protein

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Recombinant Human MAT2A protein is a Human Full Length protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

AMS2, MATA2, MAT2A, S-adenosylmethionine synthase isoform type-2, AdoMet synthase 2, Methionine adenosyltransferase 2, Methionine adenosyltransferase II, MAT 2, MAT-II

1 Images
SDS-PAGE - Recombinant Human MAT2A protein (AB78878)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MAT2A protein (AB78878)

15% SDS-PAGE showing ab78878 at approximately 46kDa.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P31153

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P31153","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MAT2A or methionine adenosyltransferase 2A is an enzyme that plays an important role in the methionine cycle by catalyzing the conversion of methionine to S-adenosylmethionine (SAM). It has a molecular mass of approximately 43 kDa. MAT2A is widely expressed in various tissues with high levels typically found in the liver and kidney. This protein has alternative names including MAT-II and AdoMet synthetase. Its activity is critical for maintaining cellular methylation processes that affect a vast array of cellular functions.
Biological function summary

Methionine adenosyltransferase 2A is essential for the synthesis of SAM which is a primary methyl donor in cellular methylation reactions. MAT2A often works as part of a larger protein complex that regulates cellular growth and division. It is not an isolated component but participates in complexes that ensure proper methyl donation throughout various biological activities. The enzyme's role in methylation impacts DNA RNA and protein modifications which are essential for gene expression regulation and cellular response.

Pathways

Methionine adenosyltransferase 2A is significant in the methionine metabolism pathway closely interlinking with the transsulfuration pathway. This pathway involvement connects MAT2A with key metabolic regulators like SAM and cystathionine beta-synthase ensuring balanced methionine homeostasis and redox status. MAT2A also interacts with proteins like MAT1A which performs similar functions in the liver showing interdependency within pathways that govern methylation and sulfur amino acid metabolism.

Dysregulation of the methionine adenosyltransferase 2A has been implicated in liver cancer and neurodegenerative diseases. Aberrant expression or mutations in MAT2A can lead to disrupted SAM synthesis which contributes to altered methylation patterns observed in hepatocellular carcinoma (HCC). Additionally changes in MAT2A expression are relevant to neurodegenerative conditions as it interacts indirectly with proteins such as MAT1A which is also involved in hepatic pathologies. Understanding MAT2A's role provides insights into potential therapeutic targets for these conditions.
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Specifications

Form

Liquid

Additional notes

ab78878 is purified using conventional chromatography techniques.

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General info

Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme : formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

Sequence similarities

Belongs to the AdoMet synthase family.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme : formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
See full target information MAT2A
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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