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AB132358

Recombinant Human Matriptase 2 protein

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Recombinant Human Matriptase 2 protein is a Human Full Length protein, in the 1 to 461 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

UNQ354/PRO618, TMPRSS6, Transmembrane protease serine 6, Matriptase-2

1 Images
SDS-PAGE - Recombinant Human Matriptase 2 protein (AB132358)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Matriptase 2 protein (AB132358)

12.5% SDS-PAGE analysis of ab132358 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

Q8IU80

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRYHFLSSLWLPFLPPPPSLPSSTVTPSLEAQVPNLRGAARGASRGWGWCQACCP","proteinLength":"Full Length","predictedMolecularWeight":"78 kDa","actualMolecularWeight":null,"aminoAcidEnd":461,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8IU80","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Membrane-bound serine protease (PubMed : 18976966, PubMed : 20518742, PubMed : 25156943, PubMed : 25588876). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed : 18408718, PubMed : 18976966, PubMed : 25156943).

Sequence similarities

Belongs to the peptidase S1 family.

Post-translational modifications

The single-chain zymogen undergoes autoproteolytic processing (PubMed:18976966, PubMed:20518742, PubMed:25156943). This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly (PubMed:18976966, PubMed:20518742, PubMed:25156943). The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization (PubMed:20518742, PubMed:25156943).

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Product protocols

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Target data

Membrane-bound serine protease (PubMed : 18976966, PubMed : 20518742, PubMed : 25156943, PubMed : 25588876). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed : 18408718, PubMed : 18976966, PubMed : 25156943).
See full target information TMPRSS6
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