Recombinant Human MBD3L1 protein is a Human Full Length protein, in the 1 to 194 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A K S S Q R K Q R D C V N Q C K S K P G L S T S I P L R M S S Y T F K R P V T R I T P H P G N E V R Y H Q W E E S L E K P Q Q V C W Q R R L Q G L Q A Y S S A G E L S S T L D L A N T L Q K L V P S Y T G G S L L E D L A S G L E H S C P M P H L A C S S D A V E I I P A E G V G I S Q L L C K Q F L V T E E D I R K Q E G K V K T V R E R L A I A L I A D G L A N E A E K V R D Q E G C P E K R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Alternative names
MBD3L, MBD3L1, Methyl-CpG-binding domain protein 3-like 1, MBD3-like protein 1
Recommended products
Recombinant Human MBD3L1 protein is a Human Full Length protein, in the 1 to 194 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q8WWY6-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A K S S Q R K Q R D C V N Q C K S K P G L S T S I P L R M S S Y T F K R P V T R I T P H P G N E V R Y H Q W E E S L E K P Q Q V C W Q R R L Q G L Q A Y S S A G E L S S T L D L A N T L Q K L V P S Y T G G S L L E D L A S G L E H S C P M P H L A C S S D A V E I I P A E G V G I S Q L L C K Q F L V T E E D I R K Q E G K V K T V R E R L A I A L I A D G L A N E A E K V R D Q E G C P E K R
- Accession
- Q8WWY6
- Protein length
- Full Length
- Amino acids
- 1 to 194
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Transcriptional repressor.
- Sequence similarities
Belongs to the MBD3L family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MBD3L1 also known as Methyl-CpG Binding Domain Protein 3-Like 1 is a protein that functions by binding to methylated DNA regions. It has a molecular weight of approximately 28 kDa. This protein is expressed in several tissues with higher expression levels observed in testis and lymphocytes. MBD3L1 interacts with other proteins involved in chromatin remodeling and gene expression regulation. It does not possess a DNA-binding domain marking its diverse role compared to other members of the MBD family.
- Biological function summary
MBD3L1 influences transcription regulation through its involvement in chromatin modification processes. It is part of a multiprotein complex that includes members like MBD2 and CHD4 which are known contributors to the nucleosome remodeling and deacetylase (NuRD) complex. This interaction facilitates the transcriptional repression activity and plays a role in establishing and maintaining DNA methylation patterns. MBD3L1's influence extends to important cellular processes such as cell differentiation.
- Pathways
One can observe MBD3L1's involvement in the epigenetic regulation of gene expression and the DNA damage response pathway. The NuRD complex where MBD3L1 is a component regulates gene silencing important for epigenetic inheritance. Interaction with proteins like HDAC1 and MTA1 shows its role in histone deacetylation and chromatin remodeling. MBD3L1's activity ensures proper cell cycle progression and genomic stability impacting cellular responses to DNA damage.
- Associated diseases and disorders
MBD3L1 has been connected to cancer and autoimmune disorders. Abnormal expression of MBD3L1 and associated complexes can result in altered gene expression patterns contributing to oncogenesis. It associates with proteins like DNMT1 in cancer implying a role in aberrant DNA methylation patterns observed in tumorigenesis. In autoimmune disorders irregular chromatin modifications mediated by MBD3L1 complex can lead to improper immune cell development and function influencing disease progression.
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1 product image
SDS-PAGE - Recombinant Human MBD3L1 protein (ab164770)
ab164770 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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Product protocols
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