Recombinant Human MBD3L1 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MBD3L1 also known as Methyl-CpG Binding Domain Protein 3-Like 1 is a protein that functions by binding to methylated DNA regions. It has a molecular weight of approximately 28 kDa. This protein is expressed in several tissues with higher expression levels observed in testis and lymphocytes. MBD3L1 interacts with other proteins involved in chromatin remodeling and gene expression regulation. It does not possess a DNA-binding domain marking its diverse role compared to other members of the MBD family.

Biological function summary

MBD3L1 influences transcription regulation through its involvement in chromatin modification processes. It is part of a multiprotein complex that includes members like MBD2 and CHD4 which are known contributors to the nucleosome remodeling and deacetylase (NuRD) complex. This interaction facilitates the transcriptional repression activity and plays a role in establishing and maintaining DNA methylation patterns. MBD3L1's influence extends to important cellular processes such as cell differentiation.

Pathways

One can observe MBD3L1's involvement in the epigenetic regulation of gene expression and the DNA damage response pathway. The NuRD complex where MBD3L1 is a component regulates gene silencing important for epigenetic inheritance. Interaction with proteins like HDAC1 and MTA1 shows its role in histone deacetylation and chromatin remodeling. MBD3L1's activity ensures proper cell cycle progression and genomic stability impacting cellular responses to DNA damage.

MBD3L1 has been connected to cancer and autoimmune disorders. Abnormal expression of MBD3L1 and associated complexes can result in altered gene expression patterns contributing to oncogenesis. It associates with proteins like DNMT1 in cancer implying a role in aberrant DNA methylation patterns observed in tumorigenesis. In autoimmune disorders irregular chromatin modifications mediated by MBD3L1 complex can lead to improper immune cell development and function influencing disease progression.