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AB172163

Recombinant Human MBIP protein

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Recombinant Human MBIP protein is a Human Full Length protein, in the 1 to 344 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

BM-015, MBIP, MAP3K12-binding inhibitory protein 1, MAPK upstream kinase-binding inhibitory protein, MUK-binding inhibitory protein

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SDS-PAGE - Recombinant Human MBIP protein (AB172163)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MBIP protein (AB172163)

SDS-PAGE analysis of ab172163.

Lane 1 : Non-reduced

Lane 2 : Reduced

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NS73

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 8 Constituents: 0.24% Tris

storage-buffer

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Complementary Products

Primary Antibodies

AB186750

Anti-MBIP antibody [EPR13951]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MBIP antibody [EPR13951] (AB186750)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMAAATEHNRPSSGDRNLERRCSPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVYTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLPLEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"42.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":344,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NS73","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MBIP also known as Mps-One Binder kinase activator-like protein 1 acts mechanically by being a component of certain cellular complexes involved in intracellular signaling. It has a molecular mass of approximately 25 kDa. Expression of MBIP occurs in many tissues but it is found at higher levels in brain and kidney tissues suggesting its significant role in these areas.
Biological function summary

MBIP regulates signaling pathways that control cell growth development and differentiation. As a part of the c-Jun N-terminal kinase (JNK) signalosome complex MBIP influences pathways that mediate responses to stress and inflammatory stimuli. The presence of MBIP in these complexes emphasizes its role in modulating the cellular response to environmental changes shedding light on how it contributes to maintaining cellular homeostasis.

Pathways

MBIP functions within the JNK signaling and the domino effect on MAP kinase pathways. In the JNK pathway MBIP interacts closely with proteins such as MKK4 and JNKs to ensure proper signal transduction and cellular outcomes. Its activity helps mediate cellular responses modulating processes like apoptosis and cell survival indicating its importance in maintaining cellular balance and health.

MBIP shows relevance to conditions like cancer and neurodegenerative diseases. Aberrant MBIP expression or activity can disrupt the JNK pathway leading to uncontrolled cell proliferation in cancer or altered neuronal functioning in conditions like Alzheimer's disease. Connections between MBIP and other proteins such as JNKs and MKK4 highlight its influence on pathological developments in these disorders providing a critical link between cellular signaling and disease progression.
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General info

Function

Functions as part of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed : 19103755). Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway (PubMed : 10801814). Together with MOCS2B, inhibits the activity of stress kinase EIF2AK2/PKR; this may lead to effects such as suppression of JNK activation and subsequent stress-responsive transcription, or suppression of eIF2a phosphorylation to favor translation (PubMed : 26705305).

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Product protocols

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Target data

Functions as part of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed : 19103755). Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway (PubMed : 10801814). Together with MOCS2B, inhibits the activity of stress kinase EIF2AK2/PKR; this may lead to effects such as suppression of JNK activation and subsequent stress-responsive transcription, or suppression of eIF2a phosphorylation to favor translation (PubMed : 26705305).
See full target information MBIP
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Product promise

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