Recombinant Human MBNL2 protein
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(1 Publication)
Recombinant Human MBNL2 protein is a Human Full Length protein, in the 1 to 373 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
MBLL, MBLL39, MLP1, MBNL2, Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, Muscleblind-like protein-like 39
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human MBNL2 protein (AB160843)
ab160843 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MBNL2 plays significant roles in the control of RNA splicing editing and transport. It does not work alone but often operates as part of a larger protein complex. The protein influences post-transcriptional gene expression and is essential for maintaining the proper isoform expression of various target proteins. This regulation affects development differentiation and function of muscle and neuronal tissues. MBNL2 serves as an important player in adjusting splicing patterns in response to cellular signals and stresses impacting the cell's adaptability and function.
Pathways
MBNL2 is intimately involved in the myotonic dystrophy splicing pathway affecting muscle and neuron function. It has a functional relationship with other muscleblind-like proteins such as MBNL1. These proteins collectively collaborate to regulate exon inclusion and exclusion in response to physiological changes. Furthermore MBNL2 participates in the circadian rhythm pathway influencing how cells adapt to daily environmental variations. It modulates the expression and processing of transcripts central to maintaining circadian clock accuracy and stability.
Specifications
Form
Liquid
General info
Function
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity). Regulates NCOR2 alternative splicing (By similarity). Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
Sequence similarities
Belongs to the muscleblind family.
Subcellular localisation
Nucleus
Target data
Publications (1)
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Investigative ophthalmology & visual science 60:3980-3991 PubMed31560764
2019
Applications
Unspecified application
Species
Unspecified reactive species
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