Recombinant Human MDP1 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MDP1 also known as Magnesium-dependent Phosphatase 1 is a protein involved in dephosphorylation processes. It has a mass of approximately 20 kDa. Researchers detect its expression in various tissues with considerable levels in the brain and liver. MDP1 assists in hydrolyzing phosphate groups from its substrate molecules which modifies their functional activity. This action is essential for manipulating signal transduction and metabolic pathways that rely on reversible phosphorylation.

Biological function summary

MDP1 functions as a magnesium-dependent enzyme that regulates many metabolic activities by modulating the phosphorylation status of specific substrates. While it doesn’t form a part of any known complex MDP1 plays a significant role in maintaining intracellular phosphate balance. Its action impacts processes like glucose metabolism and energy production where it exerts influence over key enzymatic steps.

Pathways

MDP1 plays an integral role in both the insulin signaling pathway and glycolytic processes. It interacts with proteins involved in glucose homeostasis such as IRS1 to manage energy-generating processes. In the insulin signaling pathway MDP1 facilitates the conversion of high-energy substrates ensuring efficient energy production and glucose utilization. This function ties it closely to the regulation of blood sugar levels and carbohydrate metabolism.

MDP1 holds relevance in conditions like diabetes and metabolic syndrome. It affects disease progression by influencing glucose metabolism-related proteins. For example disturbances in MDP1 activity can lead to altered interaction with insulin receptor signaling proteins worsening insulin resistance. Another disorder linked to MDP1 is neurodegeneration where abnormal phosphate transfer activity compromises neuronal health. Changes in MDP1 expression or function might disrupt pathways involving proteins such as Tau leading to neurodegenerative diseases progression.