Recombinant Human MED3 protein
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Recombinant Human MED3 protein is a Human Full Length protein, in the 1 to 70 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
CRSP34, CRSP8, MED27, Mediator of RNA polymerase II transcription subunit 27, Cofactor required for Sp1 transcriptional activation subunit 8, Mediator complex subunit 27, P37 TRAP/SMCC/PC2 subunit, Transcriptional coactivator CRSP34, CRSP complex subunit 8
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human MED3 protein (AB160491)
ab160491 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Functions of MED3 extend to the facilitation of transcriptional activation processes. Being a part of the Mediator complex MED3 influences RNA polymerase II-dependent transcription in eukaryotic cells. It works closely with other core subunits to recruit the complex to gene promoters and enable efficient transcription initiation. MED3 by interacting with transcriptional regulators adjusts the transcriptional output necessary for cell growth and differentiation.
Pathways
Studies show that MED3 is involved in the regulation of Wnt signaling and the Notch signaling pathways. These pathways are key in cell fate determination and developmental processes. The MED3 protein intersects with the activities of other transcriptional regulators like beta-catenin in the Wnt pathway emphasizing its impact on important developmental gene expression.
Specifications
Form
Liquid
General info
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence similarities
Belongs to the Mediator complex subunit 27 family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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