Recombinant Human MED7 protein (His tag N-Terminus)
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Recombinant Human MED7 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 233 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
ARC34, CRSP9, MED7, Mediator of RNA polymerase II transcription subunit 7, hMED7, Activator-recruited cofactor 34 kDa component, Cofactor required for Sp1 transcriptional activation subunit 9, Mediator complex subunit 7, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33, CRSP complex subunit 9
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MED7 protein (His tag N-Terminus) (AB131673)
SDS-PAGE of ab131673 (3µg) under reducing condition and visualized by coomassie blue stain.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These components coordinate as part of Mediator complex which regulates transcription by acting as bridge between DNA-bound transcriptional regulators and RNA polymerase II. MED7 contributes to the structural integrity of Mediator complex affecting transcriptional activation processes necessary for gene expression. The protein's roles link it directly to cell growth differentiation and response to various stimuli indicating its importance in diverse cellular processes.
Pathways
MED7 integrates itself into transcription regulation pathways especially interacting with other subunits like MED1 and MED14. The Mediator complex functions in the pathway responsible for transferring information from transcription factors to RNA polymerase II. This involves interacting with multiple pathways including Notch signaling and Wnt signaling serving as coordinator between transcriptional regulators and transcription machinery.
Specifications
Form
Liquid
Additional notes
Purified using conventional chromatography techniques.
General info
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence similarities
Belongs to the Mediator complex subunit 7 family.
Post-translational modifications
Constitutively sumoylated.
Subcellular localisation
Nucleus
Target data
Complementary Products
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MED7 antibody [EPR15410] (AB187146)](https://content.abcam.com/products/images/med7-antibody-epr15410-ab187146--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img131225.jpg)
Product promise
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