Recombinant Human MEMO1 protein
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Recombinant Human MEMO1 protein is a Human Full Length protein, in the 1 to 297 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
C2orf4, MEMO, NS5ATP7, CGI-27, MEMO1, Protein MEMO1, C21orf19-like protein, Hepatitis C virus NS5A-transactivated protein 7, Mediator of ErbB2-driven cell motility 1, HCV NS5A-transactivated protein 7, Mediator of cell motility 1, Memo-1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human MEMO1 protein (AB130046)
15% SDS-PAGE analysis of 3 μg of ab130046.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MEMO1 influences cell motility and cytoskeletal dynamics. It acts as an important player by interacting with receptor tyrosine kinases although MEMO1 does not form part of larger protein complexes. MEMO1 also regulates the intracellular localization of important signaling molecules impacting how cells organize their internal structures. It importantly affects cell migration demonstrating functions that are important for both normal physiology and disease progression.
Pathways
MEMO1 greatly interacts with intracellular signaling networks like the Ras and PI3K pathways. These pathways are important for cell survival and growth. MEMO1 influences these pathways by modulating kinase activities and enhancing signal propagation. It frequently works alongside proteins such as EGFR (Epidermal Growth Factor Receptor) and FAK (Focal Adhesion Kinase) which are important for transmitting extracellular cues to intracellular responses.
Specifications
Form
Liquid
Additional notes
ab130046 was purified using conventional chromatography techniques.
General info
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Sequence similarities
Belongs to the MEMO1 family.
Target data
Complementary Products
Product promise
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