JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB114829

Recombinant Human MEOX 2 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human MEOX 2 protein is a Human Full Length protein, in the 1 to 303 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

GAX, MOX2, MEOX2, Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2

1 Images
SDS-PAGE - Recombinant Human MEOX 2 protein (AB114829)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MEOX 2 protein (AB114829)

ab114829 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Accession

P50222

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein).</p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL","proteinLength":"Full Length","predictedMolecularWeight":"59.07 kDa","actualMolecularWeight":null,"aminoAcidEnd":303,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P50222","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MEOX2 protein also known as Mesenchyme Homeobox 2 or GAX is a homeobox-containing transcription factor with a mass of approximately 34 kDa. MEOX2 is expressed in developing mesoderm and neural crest during embryonic development. In adults its expression continues in various tissues including skeletal muscle and some parts of the central nervous system. This expression pattern indicates its role in both early development and maintenance of specific tissues.
Biological function summary

MEOX2 regulates the differentiation of mesodermal cells and contributes to skeletal muscle development. It acts as a transcription factor influencing the expression of a variety of downstream genes involved in cell cycle control and tissue morphogenesis. MEOX2 functions within a complex network of homeobox genes working together with other transcription factors to modulate cellular differentiation and organogenesis.

Pathways

The MEOX2 protein plays a significant role in the Wnt signaling and TGF-beta pathways. These pathways are important in cellular growth differentiation and development processes. MEOX2 interacts with proteins such as beta-catenin in the Wnt pathway influencing gene transcription linked to cell proliferation and differentiation. This coordination ensures the proper development and function of tissues where MEOX2 is expressed.

MEOX2 involvement has been linked to vascular diseases and muscular dystrophies. Altered expression of MEOX2 can disrupt vascular endothelium function contributing to the progression of vascular diseases like atherosclerosis. In muscular dystrophies MEOX2 interacts with other proteins such as myogenin and MyoD potentially affecting muscle cell differentiation and regeneration. Understanding these interactions and MEOX2's roles could provide insights into therapeutic targets for these conditions.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed : 17074759, PubMed : 20516212, PubMed : 22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed : 17074759, PubMed : 22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed : 22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed : 17074759, PubMed : 20516212, PubMed : 22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed : 17074759, PubMed : 22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed : 22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).
See full target information MEOX2
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB262916

Anti-MEOX 2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEOX 2 antibody (AB262916)

  • 0
  • 0
Proteins & Peptides

AB167892

Recombinant Human MEOX2 protein

SDS-PAGE - Recombinant Human MEOX2 protein (AB167892)

  • 0
  • 0
Proteins & Peptides

AB87412

Recombinant Human GMFG protein

SDS-PAGE - Recombinant Human GMFG protein (AB87412)

  • 0
  • 0
Proteins & Peptides

AB276956

Recombinant Mouse ESAM protein (His tag)

SDS-PAGE - Recombinant Mouse ESAM protein (His tag) (AB276956)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com