Recombinant Human Meprin beta protein (His tag)

Specifications

Form

Lyophilized

General info

Function

Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include : FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Cleaves also the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides (PubMed : 27180357).

Post-translational modifications

Phosphorylated by PKC at multiple sites of its cytoplasmic part. Phosphorylation dcreases activity at the cell surface, leading to diminished substrate cleavage.. N-glycosylated; contains high mannose and/or complex biantennary structures.. O-glycosylation protect the C-terminal region from proteolytic cleavage and diminish secretion, this seems to be specific to human.. Proteolytically activated by trypsin in the intestinal lumen and kallikrein-related peptidases in other tissues.