Recombinant Human MESDC1 protein - BSA and Azide free is a Human Full Length protein, in the 1 to 362 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.
MESDC1, TLNRD1, Talin rod domain-containing protein 1, Mesoderm development candidate 1
Recombinant Human MESDC1 protein - BSA and Azide free is a Human Full Length protein, in the 1 to 362 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
ab180334 is purified using conventional chromatography techniques.
Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.
MESDC1 also known as Mesoderm Development Candidate 1 functions as a chaperone involved in protein folding and quality control within the endoplasmic reticulum. This protein has a molecular mass of approximately 24 kDa. Researchers have observed MESDC1 expression in various tissues and it plays an important role in cellular development and maintenance. It takes part in ensuring correct protein conformation preventing aggregation and assisting in the stabilization of proteins.
MESDC1 helps facilitate the proper assembly and transport of low-density lipoprotein receptors (LDLR). While it is not part of a complex itself it interacts with developing lipoprotein receptors aiding their maturation and functional activity. This activity is essential for maintaining lipid balance and ensuring cholesterol homeostasis within cells. By ensuring receptor maturation MESDC1 indirectly supports cellular uptake and regulation of lipid components.
MESDC1 is mainly associated with the LDL receptor pathway which is significant for cholesterol metabolism. It works closely with proteins related to this pathway such as LDLR assisting its proper function. Another related pathway is the endoplasmic reticulum quality control pathway where MESDC1 plays an instrument role in monitoring protein assembly and integrity ensuring only properly folded proteins advance towards their final cellular destinations.
MESDC1 has associations with lipid metabolism disorders due to its role in LDL receptor processing. One such disorder is familial hypercholesterolemia where dysfunctional LDL receptor activity leads to high cholesterol levels. MESDC1's relationship with LDLR ties it to this disorder as any malfunction in this protein folding process can disrupt cholesterol uptake. Another potential connection is to neurodegenerative conditions where protein misfolding contributes to disease progression suggesting that MESDC1 might influence the development and function of neural cells through its quality control activities.
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15% SDS-PAGE analysis of ab180334 (3μg).
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