Recombinant Human MESDC2 protein
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Recombinant Human MESDC2 protein is a Human Full Length protein, in the 34 to 234 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
KIAA0081, MESDC2, MESDM, UNQ1911/PRO4369, MESD, LRP chaperone MESD, LDLR chaperone MESD, Mesoderm development LRP chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MESDC2 protein (AB104671)
15% SDS-PAGE showing ab104671 at approximately 24.9kDa (3μg).
Note : Real molecular weight on SDS-PAGE is shifted up compared to predicted molecular weight.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The function of MESDC2 involves regulation of cholesterol homeostasis and cellular lipid uptake processes. MESDC2 acts as part of the molecular machinery that ensures the proper folding of specific receptor proteins within the ER especially the LDL receptor family. It is critical for receptor maturation before they exit the ER and proceed to the Golgi. MESDC2 therefore indirectly influences membrane-bound receptor availability impacting signaling pathways that depend on these receptors.
Pathways
MESDC2 is primarily involved in lipid metabolism and transport pathways. It facilitates the LDL receptor's correct folding impacting cholesterol uptake and lipid homeostasis. These pathways are interconnected with proteins such as PCSK9 which modulates the recycling and degradation of LDL receptors. MESDC2's role supports efficient cholesterol transport preventing disruptions that might otherwise lead to cellular and systemic imbalances.
Specifications
Form
Liquid
Additional notes
ab104671 is purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
General info
Function
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed : 15014448). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane (PubMed : 17488095). Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity).
Sequence similarities
Belongs to the MESD family.
Target data
Complementary Products
Product promise
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