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AB168057

Recombinant Human Methionine Aminopeptidase 2/p67 protein

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Recombinant Human Methionine Aminopeptidase 2/p67 protein is a Human Full Length protein, in the 1 to 478 aa range, expressed in Insect cells, with >95%, suitable for SDS-PAGE.

View Alternative Names

MNPEP, P67EIF2, METAP2, Methionine aminopeptidase 2, MAP 2, MetAP 2, Initiation factor 2-associated 67 kDa glycoprotein, Peptidase M, p67, p67eIF2

Key facts

Purity

>95% SDS-PAGE

Expression system

Insect cells

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P50579

Animal free

No

Carrier free

No

Species

Human

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.48% HEPES, 0.001% Cobalt chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Methionine Aminopeptidase 2
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Sequence info

[{"sequence":"MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY","proteinLength":"Full Length","predictedMolecularWeight":"70 kDa","actualMolecularWeight":null,"aminoAcidEnd":478,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Insect cells","accessionNumber":"P50579","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab168057 was purified by chromatography.

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General info

Function

The protein expressed by the MAP2 gene cotranslationally removes the N-terminal methionine from nascent proteins, particularly when the second residue is small and uncharged. In comparison to METAP1, the catalytic activity of human METAP2 towards Met-Val peptides is consistently much higher, indicating its role in processing proteins with N-terminal Met-Val and Met-Thr sequences in vivo. Additionally, it protects the eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases, such as EIF2AK2/PKR and EIF2AK1/HCR, playing a critical role in the regulation of protein synthesis. This supplementary information is collated from multiple sources and compiled automatically.

Sequence similarities

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.

Post-translational modifications

Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.

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Product protocols

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Target data

The protein expressed by the MAP2 gene cotranslationally removes the N-terminal methionine from nascent proteins, particularly when the second residue is small and uncharged. In comparison to METAP1, the catalytic activity of human METAP2 towards Met-Val peptides is consistently much higher, indicating its role in processing proteins with N-terminal Met-Val and Met-Thr sequences in vivo. Additionally, it protects the eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases, such as EIF2AK2/PKR and EIF2AK1/HCR, playing a critical role in the regulation of protein synthesis. This supplementary information is collated from multiple sources and compiled automatically.
See full target information METAP2
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Primary Antibodies

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Primary Antibodies

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