Recombinant Human METRNL protein (His tag)
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Recombinant Human METRNL protein (His tag) is a Human Full Length protein, in the 46 to 311 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
Meteorin-like protein, Subfatin, METRNL
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human METRNL protein (His tag) (AB225666)
Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225666 with 5% enrichment gel and 15% separation gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Meteorin-like protein influences energy expenditure and thermogenesis. It enhances the browning of white adipose tissue leading to increased metabolic activity. METRNL acts as an upstream regulator for several metabolic pathways and interacts with cells involved in immune response signifying a potential role in regulating inflammation. While METRNL itself does not form a large protein complex it interacts with a network of signaling molecules that mediate its effects on energy balance.
Pathways
The action of Meteorin-like protein integrates into pathways influencing the immune system and metabolism. METRNL has a functional link to the signal transducer and activator of transcription 3 (STAT3) pathway where it modulates cellular processes related to metabolism and inflammation. Additionally METRNL impacts the AMP-activated protein kinase (AMPK) pathway critical for energy homeostasis through its ability to enhance the browning of adipose tissue. These pathways underline METRNL's role in metabolic regulation and immune responses.
Specifications
Form
Liquid
General info
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Sequence similarities
Belongs to the meteorin family.
Target data
Complementary Products
Product promise
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