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AB163864

Recombinant Human METT11D1 protein (GST tag N-Terminus)

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Recombinant Human METT11D1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 456 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

METT11D1, METTL17, False p73 target gene protein, Methyltransferase 11 domain-containing protein 1, Methyltransferase-like protein 17

1 Images
SDS-PAGE - Recombinant Human METT11D1 protein (GST tag N-Terminus) (AB163864)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human METT11D1 protein (GST tag N-Terminus) (AB163864)

ab163864 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9H7H0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAAALKCLLTLGRWCPGLGVAPQARALAALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLGSAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLENPDLSQTEEKLRGAVLHALRKTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEPYIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":456,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9H7H0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METTL11D also known as METT11D1 is a protein that functions as a methyltransferase. It plays an important role in the methylation of proteins specifically on lysine residues which adds a methyl group to these amino acids. METTL11D has a molecular weight of approximately 33 kDa. It is expressed in various tissues including the liver brain and kidney. This protein is intracellular predominantly found in the cytoplasm and nucleus of cells where it exerts its enzymatic functions.
Biological function summary

METTL11D is involved in post-translational modifications of histones and other proteins which affect their activity and interactions. These modifications can alter chromatin structure and regulate gene expression. METTL11D works as part of a larger methyltransferase complex interacting with co-factors to facilitate methylation processes. This protein’s activity can influence cellular processes like DNA repair and transcription regulation impacting cell growth and differentiation.

Pathways

METTL11D's methyltransferase function plays a role in the epigenetic pathway where it impacts chromatin modification. This pathway is important for regulating gene accessibility and transcription. METTL11D interacts with histones and other proteins such as SETD proteins to modulate gene expression through chromatin remodeling. Another significant involvement of METTL11D is in protein degradation pathways where methylation marks proteins for identification by the ubiquitin-proteasome system influencing protein stability and turnover.

METTL11D has been linked with cancer and neurodegenerative diseases. In cancer the protein's role in methylation can lead to dysregulation of gene expression patterns contributing to tumorigenesis and cancer progression. In some neurodegenerative conditions altered methylation of proteins where METTL11D functions may affect protein aggregation and neuronal survival. Moreover METTL11D's interaction with proteins like HDACs has implications in these diseases as they are also involved in maintaining proper histone acetylation and gene transcription balance.
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Specifications

Form

Liquid

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General info

Function

Mitochondrial ribosome (mitoribosome) assembly factor (PubMed : 36482135, PubMed : 38199006). Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body (PubMed : 36482135). Probable inactive methyltransferase : retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity (PubMed : 38234605).

Sequence similarities

Belongs to the methyltransferase superfamily. Rsm22 family.

Subcellular localisation

Mitochondrion matrix

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Product protocols

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Target data

Mitochondrial ribosome (mitoribosome) assembly factor (PubMed : 36482135, PubMed : 38199006). Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body (PubMed : 36482135). Probable inactive methyltransferase : retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity (PubMed : 38234605).
See full target information METTL17
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