Recombinant Human METTL11A protein (His tag)
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Recombinant Human METTL11A protein (His tag) is a Human Full Length protein, in the 1 to 223 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
View Alternative Names
C9orf32, METTL11A, NRMT, NRMT1, AD-003, NTMT1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, Alpha N-terminal protein methyltransferase 1A, Methyltransferase-like protein 11A, N-terminal RCC1 methyltransferase, X-Pro-Lys N-terminal protein methyltransferase 1A, NTM1A
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human METTL11A protein (His tag) (AB211312)
15% SDS-PAGE analysis of ab211312 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The enzyme influences protein interactions by modifying proteins at the molecular level impacting their stability and function. METTL11A contributes to various processes including protein repair and turnover mechanisms. It may operate independently or within larger protein complexes though further research is necessary to identify specific complex partners. This enzymatic activity is fundamental for maintaining protein homeostasis and ensuring proper cellular function.
Pathways
METTL11A engages in the protein methylation pathway which is vital for regulating protein function and interactions. This pathway often involves other key proteins such as PCMT1 that work together to methylate proteins and modify their activities. Additionally METTL11A plays a significant role in the protein repair pathway where it repairs damaged proteins assisting in the prevention of cellular stress and damage.
Specifications
Form
Liquid
Additional notes
ab211312 was purified using conventional chromatography techniques.
General info
Function
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed : 24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
Sequence similarities
Belongs to the methyltransferase superfamily. NTM1 family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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