Recombinant Human METTL7A protein
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Recombinant Human METTL7A protein is a Human Full Length protein, in the 1 to 244 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
METTL7A, PRO0066, UNQ1902/PRO4348, TMT1A, Thiol S-methyltransferase TMT1A, Methyltransferase-like protein 7A, N6-adenosine-methyltransferase TMT1A, Protein AAM-B, Thiol methyltransferase 1A
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human METTL7A protein (AB161809)
ab161809 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
METTL7A is important for maintaining cellular homeostasis and has a role in lipid metabolism. Although details about its association with specific protein complexes are limited METTL7A influences processes like lipid droplet formation and energy balance. Its expression levels indicate that it could affect the regulation of lipid accumulation and alterations may impact metabolic functions.
Pathways
Research reveals that METTL7A is involved in metabolic pathways pertinent to lipid and energy regulation. The protein is a part of the lipid metabolism pathway interacting with other proteins like PNPLA3 which is significant in lipid droplet biology. METTL7A interactions influence how cells store and manage lipids highlighting its importance in maintaining lipid equilibrium in cells.
Specifications
Form
Liquid
General info
Function
Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed : 37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed : 34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed : 34226523, PubMed : 34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed : 19773358).. (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.
Sequence similarities
Belongs to the methyltransferase superfamily.
Post-translational modifications
Methylated at lysine residues most likely by EZH2.
Target data
Complementary Products
Product promise
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