JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB165837

Recombinant Human METTL7B protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human METTL7B protein is a Human Full Length protein, in the 1 to 194 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

METTL7B, UNQ594/PRO1180, TMT1B, Thiol S-methyltransferase TMT1B, Methyltransferase-like protein 7B, Thiol S-methyltransferase METTL7B

1 Images
SDS-PAGE - Recombinant Human METTL7B protein (AB165837)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human METTL7B protein (AB165837)

ab165837 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q6UX53

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":194,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6UX53","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

METTL7B also known as Methyltransferase-like protein 7B is an enzyme encoded by the METTL7B gene. Mechanically it functions as a putative S-adenosylmethionine-dependent methyltransferase. It has a mass of approximately 23 kDa. This protein is expressed in various tissues with higher expression levels in the lung liver and adipose tissue. The presence of METTL7B in these tissues suggests its roles in multiple physiological processes.
Biological function summary

METTL7B plays a role in lipid metabolism contributing to the biosynthesis and processing of complex lipids. It could be involved in cellular responses to metabolic stresses. METTL7B has not been identified as part of any larger protein complexes but may interact with other proteins involved in lipid metabolic pathways. Its expression levels can influence the metabolic flexibility of cells impacting lipid homeostasis.

Pathways

METTL7B integrates into lipid and energy metabolism. It potentially interacts with the phosphatidylinositol signaling system a pathway important for regulating cellular processes including growth and metabolism. The protein may also relate to key regulatory proteins such as insulin receptor substrates which play roles in metabolic signaling pathways that govern energy homeostasis within cells.

METTL7B has associations with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). The dysfunction in its methyltransferase activity could impact lipid accumulation and metabolic regulation contributing to these conditions. Additionally its interaction with metabolic regulators like AMP-activated protein kinase (AMPK) highlights its importance in disease mechanisms where lipid and energy imbalances are involved.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol.

Sequence similarities

Belongs to the methyltransferase superfamily.

style
left-column

Product protocols

style
left-column

Target data

Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol.
See full target information TMT1B
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB110134

Anti-METTL7B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-METTL7B antibody (AB110134)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB132441

Recombinant Human ATP6V1A protein

SDS-PAGE - Recombinant Human ATP6V1A protein (AB132441)

  • 0
  • 0
Primary Antibodies

AB259976

Anti-Synaptopodin antibody [EPR23922-79]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Synaptopodin antibody [EPR23922-79] (AB259976)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com