Recombinant Human MFAP3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MFAP3 protein also known as Microfibrillar-associated protein 3 is an important structural component in the matrix. It weighs approximately 31 kDa. MFAP3 is expressed mainly in connective tissues where it interacts closely with elastin and other extracellular matrix proteins. The expression of MFAP3 is significant in tissues requiring elasticity and strength like skin and blood vessels.

Biological function summary

MFAP3 contributes to the assembly and function of microfibrils. It acts as a supporting element within the extracellular matrix by aiding in the deposition and stabilization of elastin fibers. MFAP3 becomes integrated within the microfibrillar network which is important for maintaining tissue integrity and elasticity. The interactions between MFAP3 and elastin-associated proteins support extracellular matrix homeostasis.

Pathways

MFAP3 interacts closely with the elastic fiber formation pathways. It plays a significant role in the assembly of elastin polymers through interactions with fibrillins and latent TGF-beta-binding proteins. Through these pathways MFAP3 works alongside other proteins such as fibrillin-1 which are important for maintaining the structure of connective tissue. These interactions help modulate the properties of tissues particularly those involved in elastic fiber-rich regions.

MFAP3 shows connections to connective tissue maladies such as Marfan syndrome and cutis laxa. These conditions arise from the disruption in the structural integrity of the extracellular matrix where the protein plays a role. Changes in MFAP3 interactions particularly with proteins like fibrillin-1 in Marfan syndrome can contribute to compromised tissue integrity. Understanding MFAP3's interactions is vital for exploring potential therapeutic targets for these disorders.