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AB134547

Recombinant Human MFAP4 protein (denatured)

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Recombinant Human MFAP4 protein (denatured) is a Human Full Length protein, in the 22 to 255 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Microfibril-associated glycoprotein 4, MFAP4

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SDS-PAGE - Recombinant Human MFAP4 protein (denatured) (AB134547)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MFAP4 protein (denatured) (AB134547)

15% SDS-PAGE analysis of 3 µg ab134547.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P55083

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMVSGIRGDALERFCLQQPLDCDDIYAQGYQSDGVYLIYPSGPSVPVPVFCDMTTEGGKWTVFQKRFNGSVSFFRGWNDYKLGFGRADGEYWLGLQNMHLLTLKQKYELRVDLEDFENNTAYAKYADFSISPNAVSAEEDGYTLFVAGFEDGGAGDSLSYHSGQKFSTFDRDQDLFVQNCAALSSGAFWFRSCHFANLNGFYLGGSHLSYANGINWAQWKGFYYSLKRTEMKIRRA","proteinLength":"Full Length","predictedMolecularWeight":"29.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":255,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55083","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MFAP4 also known as Microfibril-Associated Glycoprotein 4 is a protein that plays a significant role in the extracellular matrix architecture. The molecular mass of MFAP4 is about 29 kDa. This protein is expressed in various tissues including the lung liver heart and blood vessels. As a part of the extracellular matrix MFAP4 contributes to the structural integrity and elasticity of connective tissues.
Biological function summary

MFAP4 interacts with components of the microfibrillar network. It is not a standalone entity but functions as part of a larger complex that includes elastin and microfibrillin-1. This association enhances the mechanical properties of tissues maintaining them against pressure and stretch forces. MFAP4 also participates in cellular responses such as cell adhesion and migration which are critical for tissue remodeling and repair processes.

Pathways

MFAP4 engages in multiple biological pathways related to the extracellular matrix and tissue homeostasis. The TGF-beta signaling pathway is notable as MFAP4 interacts with multiple proteins within this pathway such as fibrillin-1. Through these interactions MFAP4 influences the regulation of cell growth and differentiation. Another pathway is the integrin signaling pathway where its association with integrins supports cell adhesion and communication within the extracellular matrix.

MFAP4 shows associations with fibrosis and chronic obstructive pulmonary disease (COPD). Both conditions involve alterations in the extracellular matrix composition and function. In fibrosis the dysregulated expression of MFAP4 can affect connective tissue remodeling. Altered MFAP4 levels have also been observed in COPD where it may impact lung tissue elasticity. The protein connects with TGF-beta in the context of these diseases influencing abnormal tissue remodeling and inflammation processes.
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Specifications

Form

Liquid

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General info

Function

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed : 26601954).

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Product protocols

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Target data

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed : 26601954).
See full target information MFAP4
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