Recombinant Human MGST2 protein (GST tag N-Terminus)
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Recombinant Human MGST2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 147 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
GST2, MGST2, Microsomal glutathione S-transferase 2, Microsomal GST-2, Glutathione peroxidase MGST2, Leukotriene C4 synthase MGST2, Microsomal glutathione S-transferase II, Microsomal GST-II
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MGST2 protein (GST tag N-Terminus) (AB158890)
ab158890 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MGST2 impacts cellular defense by aiding in the detoxification of harmful compounds. It operates as part of a larger complex often associating with other glutathione transferases. By facilitating the breakdown of reactive oxygen species and electrophiles MGST2 helps in protecting cells from damage. This protection is especially important in metabolically active tissues where reactive by-products are more frequent.
Pathways
MGST2 is a component of the glutathione metabolism pathway where it collaborates closely with related proteins such as GSTM1 and GSTT1. It also plays a role in the arachidonic acid metabolism pathway. MGST2 interacts with enzymes important for the synthesis of leukotrienes which are signaling molecules involved in the inflammatory response. These pathways highlight MGST2's role in maintaining cellular homeostasis and responding to stress.
Specifications
Form
Liquid
General info
Function
Catalyzes several different glutathione-dependent reactions (PubMed : 23409838, PubMed : 26066610, PubMed : 26656251, PubMed : 8703034, PubMed : 9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed : 23409838, PubMed : 9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed : 23409838, PubMed : 8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed : 23409838, PubMed : 26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed : 26656251).
Sequence similarities
Belongs to the MAPEG family.
Target data
Product promise
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