Recombinant Human MICB Protein (His-tag) (Active)
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Recombinant Human MICB Protein (His-tag) (Active) is a Human Fragment protein, in the 23 to 309 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for HPLC, SDS-PAGE, Mass Spec, FuncS.
View Alternative Names
PERB11.2, MICB, MHC class I polypeptide-related sequence B, MIC-B
- Biological Activity
Lab
Biological Activity - Recombinant Human MICB Protein (His-tag) (Active) (AB307787)
Loaded Human NKG2D, Fc Tag on Protein A Biosensor can bind Human MICB, His Tag with an affinity constant of 698 nM as determined in BLI assay (GatorBio Prime).
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human MICB Protein (His-tag) (Active) (AB307787)
Mass determination by ESI-TOF. Predicted MW is 34197.21 Da (+/- 10 Da by ESI-TOF). Observed MW is 34202.22 Da.
- HPLC
Supplier Data
HPLC - Recombinant Human MICB Protein (His-tag) (Active) (AB307787)
HPLC analysis of ab307787
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MICB Protein (His-tag) (Active) (AB307787)
SDS-PAGE analysis of ab307787
Complementary Products
Proteins & Peptides
AB307786
Recombinant Human MICA Protein (His-tag) (Active)
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Primary Antibodies
AB300485
Anti-MICB antibody [EPR26362-65]
20ul selling size|RabMAb|Recombinant|Trial Size
![Immunocytochemistry/ Immunofluorescence - Anti-MICB antibody [EPR26362-65] (AB300485)](https://content.abcam.com/products/images/micb-antibody-epr26362-65-ab300485--immunocytochemistry-immunofluorescence-img400332.jpg)
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Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MICB contributes to immune system functioning by presenting stress-induced antigens to immune cells. It does not belong to a complex but engages in interactions critical for activating cytotoxic responses. By binding to the NKG2D receptor it helps activate NK cells and certain T cell subsets which results in the elimination of damaged or transformed cells. This immune activation is important for the surveillance against cancer and infected cells maintaining tissue homeostasis.
Pathways
MICB plays a role in the stress-induced NKG2D signaling pathway and is involved in the immune response pathway. It cooperates with proteins such as NKG2D and MICA another ligand of the NKG2D receptor to initiate immune cell-mediated cytotoxicity. These pathways activate NK cells and CD8+ T cells important for removing stressed or altered cells thereby influencing the body's defense mechanisms.
Specifications
Form
Lyophilized
Additional notes
SDS-PAGE >= 95%
General info
Function
Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed : 11491531, PubMed : 11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production.
Sequence similarities
Belongs to the MHC class I family. MIC subfamily.
Post-translational modifications
Proteolytically cleaved and released from the cell surface of tumor cells.
Target data
Product promise
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