Recombinant Human MINPP1 protein (His tag)
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Recombinant Human MINPP1 protein (His tag) is a Human Full Length protein, in the 31 to 487 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.
View Alternative Names
MIPP, UNQ900/PRO1917, MINPP1, Multiple inositol polyphosphate phosphatase 1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MINPP1 protein (His tag) (AB241455)
Analysis of ab241455 by (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This enzyme modulates levels of inositol polyphosphate molecules key messengers in diverse cellular processes. MINPP1 impacts nuclear signaling and membrane trafficking affecting cellular communication. The enzyme acts independently and is not known to be part of a larger protein complex. Its activity can influence various cellular activities by regulating IP5 and IP6 levels hinting at its involvement in more intricate cellular networks.
Pathways
MINPP1 plays a role in phosphoinositide signaling and is involved in phosphate metabolism. These pathways are important for cell growth and survival. The enzyme's function can overlap with those of PTEN and INPP5 which also participate in phosphoinositide regulation. MINPP1 regulates key molecular signals impacting energy homeostasis and metabolic processes in cells.
Specifications
Form
Liquid
General info
Function
Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed : 33257696, PubMed : 36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed : 36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed : 33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed : 18413611).
Sequence similarities
Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
Post-translational modifications
N-glycosylated.
Target data
Complementary Products
Product promise
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