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AB159941

Recombinant Human MLF2 protein (GST tag N-Terminus)

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Recombinant Human MLF2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 248 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Myeloid leukemia factor 2, Myelodysplasia-myeloid leukemia factor 2, MLF2

1 Images
SDS-PAGE - Recombinant Human MLF2 protein (AB159941)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MLF2 protein (AB159941)

ab159941 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q15773

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSITDGNMPGTRPASRRMQQAGAVSPFGMLGMSGGFMDMFGMMNDMIGNMEHMTAGGNCQTFSSSTVISYSNTGDGAPKVYQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRDRAHILQRSRNHRTGDQEERQDYINLDESEAAAFDDEWRRETSRFRQQRPLEFRRLESSGAGGRRAEGPPRLAIQGPEDSPSRQSRRYDW","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":248,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q15773","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MLF2 also known as Myeloid Leukemia Factor 2 is a protein with an approximate mass of 35 kDa. It shows expression mainly in the nucleus and cytoplasm of cells. MLF2 takes part in the regulation of various cellular processes especially those involving cell growth and differentiation. Understanding its activity and expression pattern can help in dissecting its role in cellular function and disease.
Biological function summary

MLF2 contributes to cells' response to stress making it significant in maintaining cellular homeostasis. MLF2 can interact with other proteins to form complexes that regulate transcriptional processes. This regulation is important for normal cellular function and indicates that MLF2 has an influence on gene expression modulation impacting how the cell responds to different stimuli.

Pathways

MLF2 engages in the JAK/STAT signaling pathway which is important in processes like cell proliferation differentiation and apoptosis. It also interacts with the NF-kB signaling pathway important for immune response and inflammation regulation. Through these pathways MLF2 shares connections with proteins such as STAT3 and NF-kB indicating its integration into a network that maintains cellular activity and integrity.

MLF2 associates with cancer and myelodysplastic syndromes. Its altered expression or dysfunction can contribute to tumorigenesis due to its role in cell proliferation and differentiation pathways. In these disease contexts MLF2's interaction with proteins like JAK2 becomes critical as disruptions in these interactions may exacerbate disease progression. Understanding these connections helps in considering MLF2 as a potential therapeutic target in disease treatment strategies.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the MLF family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

See full target information MLF2
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