Recombinant human MLK4 protein (Active)
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Recombinant human MLK4 protein (Active) is a Human Fragment protein, in the 114 to 420 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.
View Alternative Names
KIAA1804, MLK4, MAP3K21, Mitogen-activated protein kinase kinase kinase 21, Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4
- FuncS
Supplier Data
Functional Studies - Recombinant human MLK4 protein (Active) (AB268798)
The specific activity of ab268798 was 22 nmol/min/mg in a kinase assay using MBP protein as substrate.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human MLK4 protein (Active) (AB268798)
SDS-PAGE analysis of ab268798.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MLK4 influences cell proliferation differentiation and apoptosis through its kinase activity. It is part of signaling complexes that coordinate cellular responses to external stimuli linking surface receptors to the intracellular machinery. Through these roles MLK4 exerts important effects on cellular dynamics and maintenance of normal physiological balance.
Pathways
MLK4 integrates into the JNK and p38 MAPK signaling cascades which mediate responses to stress stimuli and regulate gene expression. MLK4 interacts with various other proteins including MLK3 to modulate these pathways effectively. Furthermore its role in these pathways positions MLK4 as an important player in ensuring cells react appropriately to potential damage or stress signals.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Post-translational modifications
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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