Recombinant Human MMGT1 protein (His tag)
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Recombinant Human MMGT1 protein (His tag) is a Human Fragment protein, in the 66 to 131 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
EMC5, TMEM32, MMGT1, ER membrane protein complex subunit 5, Membrane magnesium transporter 1, Transmembrane protein 32
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MMGT1 protein (His tag) (AB276608)
SDS-PAGE analysis of ab276608
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MMGT1 ensures magnesium ion balance within cells acting as an essential transporter. It may form a part of larger protein complexes allowing for precise regulation and distribution of magnesium ions in response to cellular needs. Magnesium serves as a cofactor for many enzymes playing a part in processes such as protein synthesis and energy production highlighting the significance of MMGT1 in cellular activities. By controlling magnesium transport MMGT1 contributes to maintaining cellular stability and optimal function.
Pathways
MMGT1 has connections to key biological pathways related to magnesium metabolism and cellular ion regulation. It interacts with other proteins such as members of the TRPM family which are also involved in mediating magnesium transport and signal transduction. Magnesium plays a critical role in signal transduction pathways and helps regulate kinase activities further linking MMGT1 to important cellular signaling dynamics.
Specifications
Form
Lyophilized
General info
Function
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed : 29242231, PubMed : 29809151, PubMed : 30415835, PubMed : 32439656, PubMed : 32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed : 29242231, PubMed : 29809151, PubMed : 30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed : 29809151, PubMed : 30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed : 29242231, PubMed : 29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed : 30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (By similarity). May be involved in Mg(2+) transport (By similarity).
Sequence similarities
Belongs to the membrane magnesium transporter (TC 1.A.67) family.
Subcellular localisation
Early endosome membrane
Target data
Complementary Products
Product promise
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