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Recombinant human MMP2 protein (Active) is a Human Full Length protein, in the 110 to 660 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for FuncS.
Alternative names=72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1, MMP-2, CLG4A, MMP2
>=95% SDS-PAGE
<= 0.005 EU/µg
HEK 293 cells
Tag free
FuncS
Yes
Y N F F P R K P K W D K N Q I T Y R I I G Y T P D L D P E T V D D A F A R A F Q V W S D V T P L R F S R I H D G E A D I M I N F G R W E H G D G Y P F D G K D G L L A H A F A P G T G V G G D S H F D D D E L W T L G E G Q V V R V K Y G N A D G E Y C K F P F L F N G K E Y N S C T D T G R S D G F L W C S T T Y N F E K D G K Y G F C P H E A L F T M G G N A E G Q P C K F P F R F Q G T S Y D S C T T E G R T D G Y R W C G T T E D Y D R D K K Y G F C P E T A M S T V G G N S E G A P C V F P F T F L G N K Y E S C T S A G R S D G K M W C A T T A N Y D D D R K W G F C P D Q G Y S L F L V A A H E F G H A M G L E H S Q D P G A L M A P I Y T Y T K N F R L S Q D D I K G I Q E L Y G A S P D I D L G T G P T P T L G P V T P E I C K Q D I V F D G I A Q I R G E I F F F K D R F I W R T V T P R D K P M G P L L V A T F W P E L P E K I D A V Y E A P Q E E K A V F F A G N E Y W I Y S A S T L E R G Y P K P L T S L G L P P D V Q R V D A A F N W S K N K K T Y I F A G D K F W R Y N E V K K K M D P G F P K L I A D A W N A I P D N L D A V V D L Q G G G H S Y F F K G A Y Y L K L E N Q S L K S V K F G S I K S D W L G C
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Recombinant human MMP2 protein (Active) is a Human Full Length protein, in the 110 to 660 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for FuncS.
Alternative names=72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1, MMP-2, CLG4A, MMP2
>=95% SDS-PAGE
<= 0.005 EU/µg
HEK 293 cells
Tag free
FuncS
Yes
Fully active determined by its ability to cleave human MMP2 fluorogenic peptide substrate (MCa-PLGL-Dpa-AR-NH2.
63 kDa
110 to 660
Y N F F P R K P K W D K N Q I T Y R I I G Y T P D L D P E T V D D A F A R A F Q V W S D V T P L R F S R I H D G E A D I M I N F G R W E H G D G Y P F D G K D G L L A H A F A P G T G V G G D S H F D D D E L W T L G E G Q V V R V K Y G N A D G E Y C K F P F L F N G K E Y N S C T D T G R S D G F L W C S T T Y N F E K D G K Y G F C P H E A L F T M G G N A E G Q P C K F P F R F Q G T S Y D S C T T E G R T D G Y R W C G T T E D Y D R D K K Y G F C P E T A M S T V G G N S E G A P C V F P F T F L G N K Y E S C T S A G R S D G K M W C A T T A N Y D D D R K W G F C P D Q G Y S L F L V A A H E F G H A M G L E H S Q D P G A L M A P I Y T Y T K N F R L S Q D D I K G I Q E L Y G A S P D I D L G T G P T P T L G P V T P E I C K Q D I V F D G I A Q I R G E I F F F K D R F I W R T V T P R D K P M G P L L V A T F W P E L P E K I D A V Y E A P Q E E K A V F F A G N E Y W I Y S A S T L E R G Y P K P L T S L G L P P D V Q R V D A A F N W S K N K K T Y I F A G D K F W R Y N E V K K K M D P G F P K L I A D A W N A I P D N L D A V V D L Q G G G H S Y F F K G A Y Y L K L E N Q S L K S V K F G S I K S D W L G C
Full Length
No
Recombinant
Human
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Liquid
>=95% Purity by HPLC
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
Belongs to the peptidase M10A family.
Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.
Nucleus, Mitochondrion
Dry Ice
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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