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AB180279

Recombinant Human MMP23 protein (denatured)

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Recombinant Human MMP23 protein (denatured) is a Human Fragment protein, in the 79 to 254 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

MMP21, MMP22, MMP23B, Matrix metalloproteinase-23, MMP-23, Femalysin, MIFR-1, Matrix metalloproteinase-21, Matrix metalloproteinase-22, MMP-21, MMP-22

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SDS-PAGE - Recombinant Human MMP23 protein (denatured) (AB180279)
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Supplier Data

SDS-PAGE - Recombinant Human MMP23 protein (denatured) (AB180279)

15% SDS-PAGE analysis of ab180279 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75900

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYG","proteinLength":"Fragment","predictedMolecularWeight":"22.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":254,"aminoAcidStart":79,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75900","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein MMP23 also known as matrix metalloproteinase-23 plays a role in tissue remodeling and cellular processes. MMP23 is unique due to its membrane-type structure distinguishing it from other MMP family members. The protein weighs approximately 44 kDa. MMP23 is mainly found in a variety of tissues including the testis ovary and placenta but its expression is notably less widespread compared to other metalloproteinases.
Biological function summary

Matrix metalloproteinase-23 contributes to modulating extracellular matrix degradation. Unlike some MMPs MMP23 is part of a transmembrane complex impacting localized tissue environments. It influences cellular growth and communication through its regulatory effects on the extracellular space. Such interactions play a part in processes like cell migration and signal transduction important for normal physiological and developmental activities.

Pathways

MMP23 participates in specific biochemical pathways important for tissue repair and immune response. One significant pathway is the extracellular matrix (ECM) remodeling pathway where MMP23 interacts with other metalloproteinases such as MMP2. Additionally MMP23's activity affects signaling pathways by altering the ECM components which can influence cellular behaviors linked to proliferation and apoptosis.

Matrix metalloproteinase-23 implicates its role in certain pathologies including cancer and inflammatory diseases. Its ability to modify the extracellular matrix associates it with tumor invasion and metastasis particularly through interactions with proteins like TIMP (tissue inhibitors of metalloproteinases). Inflammatory conditions also show altered MMP23 activity indicating its potential involvement in chronic inflammation pathophysiology.
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Specifications

Form

Liquid

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General info

Function

Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Sequence similarities

Belongs to the peptidase M10A family.

Post-translational modifications

N-glycosylated.. Proteolytic cleavage might yield an active form.

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Product protocols

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Target data

Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
See full target information MMP23B
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