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AB177646

Recombinant Human MMP28 protein (denatured) (His tag N-Terminus)

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Recombinant Human MMP28 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 123 to 520 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

MMP25, UNQ1893/PRO4339, MMP28, Matrix metalloproteinase-28, MMP-28, Epilysin

1 Images
SDS-PAGE - Recombinant Human MMP28 protein (denatured) (His tag N-Terminus) (AB177646)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MMP28 protein (denatured) (His tag N-Terminus) (AB177646)

15% SDS-PAGE analysis of ab177646 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9H239

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF","proteinLength":"Full Length","predictedMolecularWeight":"47.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":520,"aminoAcidStart":123,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H239","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP28 also known as epilysin is a member of the matrix metalloproteinase family. It weighs approximately 53 kDa. This protein is primarily expressed in skin keratinocytes placenta and testis tissues. MMP28 functions mechanically as a protease responsible for the degradation of extracellular matrix components. Its regulation can impact tissue remodeling wound repair and maintenance of homeostasis in the skin and other tissues.
Biological function summary

Matrix metalloproteinase-28 (MMP28) contributes to the dynamic restructuring of tissues. Epilysin is not known to be part of a protein complex but interacts closely with other matrix components for effective extracellular matrix modulation. It helps regulate cell migration and proliferation by modifying the surrounding extracellular environment ensuring the precise orchestration of cellular behaviors during developmental and healing processes.

Pathways

The activity of MMP28 aligns importantly with the extracellular matrix degradation pathway and tissue remodeling pathway. Within these pathways MMP28 interacts with other matrix metalloproteinases such as MMP2 and MMP9. Together they participate in breaking down collagen and other matrix proteins facilitating necessary structural alterations in tissues during various biological events.

Researchers have observed MMP28’s involvement in several pathological conditions such as fibrosis and cancer. In the context of fibrosis MMP28's activity relates to irregular tissue remodeling potentially contributing to fibrotic transformation in organs. In cancer elevated MMP28 expression correlates with tumor progression and metastasis where it interacts with collagens and other extracellular matrix components enabling tumor cells to invade and spread. Insights into MMP28's relationships with other proteins like MMP9 can help develop therapeutic strategies targeting its dysregulation in these conditions.
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Specifications

Form

Liquid

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General info

Function

Can degrade casein. Could play a role in tissues homeostasis and repair.

Sequence similarities

Belongs to the peptidase M10A family.

Post-translational modifications

The precursor is cleaved by a furin endopeptidase.

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Product protocols

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Target data

Can degrade casein. Could play a role in tissues homeostasis and repair.
See full target information MMP28
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