Recombinant Human MMP6/MPP6 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMP6 also known as matrilysin-2 belongs to the matrix metalloproteinase (MMP) family which is a group of enzymes that degrade extracellular matrix components. This protein has a molecular mass of approximately 28 kDa. MMP6 is expressed in various tissues including the epithelial cells of the intestine the lungs and the liver. Because of its expression in these areas it plays a significant role in maintaining tissue structure and function.

Biological function summary

MMP6 contributes to tissue remodeling and repair processes. It is capable of breaking down various substrates such as collagen and elastin. This protein does not function in isolation; rather it works as part of a larger protein complex within the matrix metalloproteinase family. MMP6's activity is carefully regulated by tissue inhibitors of metalloproteinases (TIMPs) which helps maintain it within safe levels necessary for normal tissue physiology.

Pathways

MMP6 plays a role in two major biological pathways: the degradation of the extracellular matrix and wound healing. In the extracellular matrix degradation pathway MMP6 collaborates with other MMPs to break down matrix components ensuring proper cell migration and tissue repair. Within the wound healing process MMP6 participates in clearing injured tissue and facilitating new tissue formation. It is related to other MMPs notably MMP1 and MMP2 through these pathways helping coordinate changes to the cellular environment.

MMP6 has associations with cancer progression and chronic obstructive pulmonary disease (COPD). In cancer MMP6 can enhance the invasive potential of malignant cells by degrading the extracellular matrix thereby aiding metastasis. In COPD overactivity of MMP6 contributes to tissue damage and inflammation in the lung. It links indirectly with proteins like MMP9 in these diseases as both MMPs share similar functions in tissue remodeling and inflammation regulation.