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AB164122

Recombinant Human MMRN2 protein (GST tag N-Terminus)

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Recombinant Human MMRN2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 949 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

EMILIN3, MMRN2, Multimerin-2, EMILIN-3, Elastin microfibril interface located protein 3, EndoGlyx-1 p125/p140 subunit, Elastin microfibril interfacer 3

1 Images
SDS-PAGE - Recombinant Human MMRN2 protein (GST tag N-Terminus) (AB164122)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MMRN2 protein (GST tag N-Terminus) (AB164122)

ab164122 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9H8L6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB121639

Anti-MMRN2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MMRN2 antibody (AB121639)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB134079

Anti-CD93 antibody [EPR5386]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-CD93 antibody [EPR5386] (AB134079)

  • 0
  • 0
Primary Antibodies

AB76003

Anti-MMP9 antibody [EP1254]

RabMAb|Recombinant|KO Validated

Western blot - Anti-MMP9 antibody [EP1254] (AB76003)

  • 4
  • 12
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPYPMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWRCCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLDGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQTVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTTGQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":949,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9H8L6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMRN2 also known as Multimerin 2 is a large extracellular matrix protein with a mass of approximately 122 kDa. It is encoded by the MMRN2 gene. MMRN2 expresses itself in a variety of tissues with higher levels in the vascular endothelium and the placenta. It shows presence in blood vessels and interacts with other endothelial components. This protein binds to cell surfaces and extracellular matrix components suggesting its role in vascular biology.
Biological function summary

Multimerin 2 functions in modulating the extracellular matrix organization. It does this by interacting with various cellular surface receptors and glycoproteins potentially through multimeric structures. MMRN2 engages in producing an environment that supports cell adhesion and migration which makes it important for tissue repair and integrity. It is not generally a part of a larger complex but rather exerts influence through its interactions with several proteins and matrix molecules.

Pathways

Multimerin 2 participates in angiogenesis and blood coagulation processes. It influences the formation and remodeling of blood vessels playing a significant role in the angiogenic pathways. MMRN2 indirectly contributes to the regulation of thrombin an important enzyme in the coagulation cascade and interacts with proteins like fibrinogen and von Willebrand factor within these pathways. These interactions help maintain vascular stability and regulate blood clotting.

Multimerin 2 has been associated with cancer progression and cardiovascular diseases. Elevated levels of MMRN2 have been linked to tumor growth due to its role in promoting angiogenesis. It relates to von Willebrand factor and thrombin in the context of cardiovascular disorders contributing to irregularities in blood flow and clot formation. Understanding these connections could lead to new therapeutic strategies targeting MMRN2 to manage and treat such conditions.
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Specifications

Form

Liquid

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General info

Function

Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel (PubMed : 28435016). Affects several essential steps in angiogenesis including endothelial cell proliferation, migration, and tube formation. Positively regulates angiogenesis by acting as a ligand for CD93 receptor (PubMed : 28671670, PubMed : 28912033).

Post-translational modifications

N- and O-glycosylated.. O-fucosylated within the EMI domain (at Ser-63, Thr-67 and Thr-115) by POFUT3 and POFUT4.. Processed by matrix metalloproteinases (MMPs) including MMP9 and, to a lesser degree, by MMP2 upon angiogenic stimulation.

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Product protocols

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Target data

Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel (PubMed : 28435016). Affects several essential steps in angiogenesis including endothelial cell proliferation, migration, and tube formation. Positively regulates angiogenesis by acting as a ligand for CD93 receptor (PubMed : 28671670, PubMed : 28912033).
See full target information MMRN2
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Product promise

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