Recombinant Human MMS2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The MMS2 protein also known as UBE2V2 is a ubiquitin-conjugating enzyme variant found within cells. Unlike typical ubiquitin-conjugating enzymes MMS2 lacks the conserved active site cysteine. The MMS2 protein has a molecular mass of approximately 16 kDa and is expressed in a range of tissues including those of the human immune system. Functionally MMS2 partners with another enzyme Ubc13 to facilitate the assembly of Lys63-linked polyubiquitin chains necessary for DNA damage tolerance and repair processes.

Biological function summary

MMS2 plays a critical role in cellular responses to DNA damage. It is part of the Ubc13-MMS2 complex which contributes to the post-replication repair pathway. This complex modulates the signaling and resolution of DNA double-strand breaks. MMS2 through its role in this complex impacts cellular mechanisms for maintaining genomic integrity and preventing genomic instability.

Pathways

MMS2 takes part in the DNA damage response and NF-kappaB signaling pathways. In the process of DNA repair it works with proteins like Rad6 and Rad18 enabling cells to overcome stalled replication forks and promoting cell survival in response to DNA damage. In the NF-kappaB pathway MMS2 contributes to signaling cascades that activate immune responses and inflammation working alongside other proteins to mediate cellular responses.

MMS2 is linked to cancer and neurodegenerative diseases. Its role in DNA repair and signaling pathways connects it to tumor suppression with defects in MMS2 function potentially leading to increased susceptibility to cancer due to accumulated DNA damage. Additionally MMS2's interaction with proteins involved in neuroinflammation suggests a possible connection to neurodegenerative conditions such as Alzheimer’s disease where dysregulated inflammation and repair pathways contribute to disease pathology.