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AB95490

Recombinant Human MNDA protein

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Recombinant Human MNDA protein is a Human Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Myeloid cell nuclear differentiation antigen, MNDA

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SDS-PAGE - Recombinant Human MNDA protein (AB95490)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MNDA protein (AB95490)

15% SDS-PAGE analysis of ab95490 (3ug).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P41218

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMVNEYKKILLLKGFELMDDYHFTSIKSLLAYDLGLTTKMQEEYNRIKITDLMEKKFQGVACLDKLIELAKDMPSLKNLVNNLRKEKSKVAKKIKTQEKAPVKKINQEEVGLAAPAPTARNKLTSEARGRIPVAQKRKTPNKEKTEAKRNKVSQEQSKPPGPSGASTSAAVDHPPLPQTSSSTPSNTSFTPNQETQAQRQVDARRNVPQNDPVTVVVLKATAPFKYESPENGKSTMFHATVASKTQYFHVKVFDINLKEKFVRKKVITISDYSECKGVMEIKEASSVSDFNQNFEVPNRIIEIANKTPKISQLYKQASGTMVYGLFMLQKKSVHKKNTIYEIQDNTGSMDVVGSGKWHNIKCEKGDKLRLFCLQLRTVDRKLKLVCGSHSFIKVIKAKKNKEGPMNVN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P41218","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MNDA known as Myeloid Cell Nuclear Differentiation Antigen has a mass of approximately 45 kDa. Expression occurs mainly in myeloid cells including monocytes and granulocytes. It is encoded by the MNDA gene situated on chromosome 1q22. MNDA belongs to the HIN-200 family of proteins which are involved in various cellular activities. The protein contains a DNA-binding domain suggesting its role in transcriptional regulation.
Biological function summary

The function of MNDA is critical for the immune response and cellular differentiation. MNDA participates in regulating gene transcription in response to external stimuli. It operates in complex with other nuclear proteins to modulate the immune and inflammatory response aiming for a precise cellular behavior. MNDA's presence in myeloid cells signifies its role in the innate immune system contributing significantly to cell maturation and defense mechanisms.

Pathways

MNDA influences gene expression modifications tied to key immune response pathways. It has a noted involvement in the Toll-like receptor (TLR) signaling pathway where it helps mediate responses to pathogens. MNDA interacts with proteins such as TLR4 which plays a vital role in innate immunity. Furthermore MNDA participates in the interferon regulatory factor (IRF) pathway impacting type I interferon production and immune regulation.

MNDA has associations with myeloid malignancies and autoimmune conditions. Abnormal expression or mutation of MNDA might contribute to disease pathology in acute myeloid leukemia (AML) where it may function alongside proteins like RUNX1 a transcription factor important in hematopoiesis. Additionally MNDA expressions and mutations link to systemic lupus erythematosus (SLE) where its regulatory impact on the immune response may be disrupted influencing inflammatory pathways and immune system regulation.
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Specifications

Form

Liquid

Additional notes

purified by using conventional chromatography techniques

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General info

Function

May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
See full target information MNDA
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Complementary Products

Primary Antibodies

AB316968

Anti-MNDA antibody [EPR28267-44] - BSA and Azide free

BOND RX™ Validated|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MNDA antibody [EPR28267-44] - BSA and Azide free (AB316968)

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