Recombinant Human MOBKL2B protein is a Human Full Length protein, in the 1 to 216 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S I A L K Q V F N K D K T F R P K R K F E P G T Q R F E L H K R A Q A S L N S G V D L K A A V Q L P S G E D Q N D W V A V H V V D F F N R I N L I Y G T I C E F C T E R T C P V M S G G P K Y E Y R W Q D D L K Y K K P T A L P A P Q Y M N L L M D W I E V Q I N N E E I F P T C V G V P F P K N F L Q I C K K I L C R L F R V F V H V Y I H H F D R V I V M G A E A H V N T C Y K H F Y Y F V T E M N L I D R K E L E P L K E M T S R M C H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
Alternative names
C9orf35, MOBKL2B, MOB3B, MOB kinase activator 3B, Mob1 homolog 2b, Mps one binder kinase activator-like 2B, MOB kinase activator-like 2B
Recommended products
Recombinant Human MOBKL2B protein is a Human Full Length protein, in the 1 to 216 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q86TA1-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M S I A L K Q V F N K D K T F R P K R K F E P G T Q R F E L H K R A Q A S L N S G V D L K A A V Q L P S G E D Q N D W V A V H V V D F F N R I N L I Y G T I C E F C T E R T C P V M S G G P K Y E Y R W Q D D L K Y K K P T A L P A P Q Y M N L L M D W I E V Q I N N E E I F P T C V G V P F P K N F L Q I C K K I L C R L F R V F V H V Y I H H F D R V I V M G A E A H V N T C Y K H F Y Y F V T E M N L I D R K E L E P L K E M T S R M C H
- Accession
- Q86TA1
- Protein length
- Full Length
- Predicted molecular weight
- 27.9 kDa
- Amino acids
- 1 to 216
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
purified using conventional chromatography techniques
General info
- Function
Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
- Sequence similarities
Belongs to the MOB1/phocein family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MOBKL2B also known as MOB2 is a protein with a molecular mass of approximately 26 kDa. It is expressed in various tissues throughout the body including the brain and liver. Mechanically MOBKL2B functions as a kinase activator playing a critical role in regulating cellular processes such as cell growth and division by interacting with and modulating the activity of NDR kinases.
- Biological function summary
This protein plays an important role in maintaining cellular homeostasis. It forms part of a complex with other proteins such as the MST-NDR signaling module to influence cell proliferation and survival. By modulating kinase activities MOBKL2B contributes to the regulation of apoptosis and other cell-cycle events.
- Pathways
MOBKL2B participates in significant signaling pathways including the Hippo pathway which controls organ size by regulating cell proliferation and apoptosis. In this pathway MOBKL2B interacts with proteins like LATS1/2 kinases. MOBKL2B also has associations with the JNK signaling pathway where it influences stress responses and developmental processes.
- Associated diseases and disorders
MOBKL2B is relevant to cancer and neurodegenerative conditions. Altered expression or function of MOBKL2B can contribute to uncontrolled cell growth in cancers potentially through dysregulation of NDR kinases. In neurodegeneration its interaction with proteins such as tau might play a role in disease progression linking MOBKL2B to disorders like Alzheimer’s disease.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human MOBKL2B protein (ab177639)
15% SDS-PAGE analysis of ab177639 (3ug)
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com