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AB134527

Recombinant Human MOCS2 protein

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Recombinant Human MOCS2 protein is a Human Full Length protein, in the 1 to 188 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MCBPE, MOCO1, MOCS2, Molybdopterin synthase catalytic subunit, MOCO1-B, Molybdenum cofactor synthesis protein 2 large subunit, Molybdenum cofactor synthesis protein 2B, Molybdopterin-synthase large subunit, MOCS2B, MPT synthase large subunit

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SDS-PAGE - Recombinant Human MOCS2 protein (AB134527)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human MOCS2 protein (AB134527)

15% SDS-PAGE analysis of 3 μg ab134527.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

DDDDK tag N-Terminus His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O96007

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMSSLEISSSCFSLETKLPLSPPLVEDSAFEPSRKDMDEVEEKSKDVINFTAEKLSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWKGNKECFWASNS","proteinLength":"Full Length","predictedMolecularWeight":"25 kDa","actualMolecularWeight":null,"aminoAcidEnd":188,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O96007","tags":[{"tag":"DDDDK","terminus":"N-Terminus"},{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOCS2 also known as molybdenum cofactor synthesis 2 plays a mechanical role in the biosynthesis of molybdenum cofactor. The protein has a molecular mass of approximately 20 kDa. MOCS2 is mainly expressed in the liver and kidneys where it contributes to various cellular processes. It consists of two isoforms A and B which play unique roles in facilitating the conversion of precursor molecules into active cofactors.
Biological function summary

The molybdenum cofactor synthesis process requires several components to function effectively. MOCS2 is part of the molybdenum cofactor synthesis complex which is essential for proper enzyme activity that utilizes the molybdenum cofactor. Enzymes requiring this cofactor include xanthine oxidase and aldehyde oxidase both of which are critical for metabolizing purines and aldehydes. The formation and regulation of this complex ensure efficient enzyme activity across different tissues.

Pathways

MOCS2 participates in the molybdenum cofactor biosynthesis pathway. It aligns with the sulfur transfer pathway where it interacts closely with MOCS1 another molybdenum cofactor synthesis protein. Both proteins coordinate to ensure sufficient cofactor production for catalytic reactions. These interactions allow for the proper function of enzymes like sulfite oxidase linking MOCS2 to essential metabolic processes.

Mutations or dysfunction in MOCS2 can lead to molybdenum cofactor deficiency a rare metabolic disorder. This disorder results in neurological symptoms due to the accumulation of toxic substances unmetabolized due to insufficient cofactor. MOCS2’s relationship with MOCS1 is significant as alterations in either can cause similar metabolic disruptions leading to the disease. Understanding MOCS2's role in these pathways provides insights into therapeutic strategies for affected individuals.
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Specifications

Form

Liquid

Additional notes

ab134527 is purified using conventional chromatography techniques.

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General info

Function

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.

Sequence similarities

Belongs to the MoaE family. MOCS2B subfamily.

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Product protocols

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Target data

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
See full target information MOCS2
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Complementary Products

Primary Antibodies

AB230013

Anti-MOCS2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MOCS2 antibody (AB230013)

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