JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB130051

Recombinant Human MOG1 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human MOG1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 186 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MOG1, RANGNRF, HSPC165, HSPC236, MDS5, RANGRF, Ran guanine nucleotide release factor, RanGNRF, Ran-binding protein MOG1

1 Images
SDS-PAGE - Recombinant Human MOG1 protein (His tag N-Terminus) (AB130051)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human MOG1 protein (His tag N-Terminus) (AB130051)

SDS-PAGE analysis of ab130051 (3µg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9HD47

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ","proteinLength":"Full Length","predictedMolecularWeight":"23 kDa","actualMolecularWeight":null,"aminoAcidEnd":186,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HD47","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MOG1 also known as RanBP1-like protein MOG1 serves as an important regulator in the nuclear transport processes. This protein has a mass of approximately 25 kDa. MOG1 is expressed predominantly in brain tissue where it facilitates the movement of molecules between the nucleus and the cytoplasm. The presence of MOG1 in other tissues like the heart and skeletal muscle is also seen indicating its diverse expression profile in the human body.
Biological function summary

MOG1 interacts with the Ran GTPase system to mediate nuclear transport important for cellular function. MOG1 forms part of a complex that includes various nuclear import and export proteins. Its role extends to ensuring effective regulation of Ran GTPase activity maintaining the directionality of nuclear transport. This interaction allows MOG1 to influence cell cycle progression by regulating the transport of key regulatory proteins into the nucleus.

Pathways

MOG1 plays an essential role in the Ran GTPase signaling pathway. This pathway impacts the nuclear import and export processes contingent on the function of proteins such as Ran and importin-beta. MOG1 facilitates the conversion of Ran-GDP to Ran-GTP thereby enabling nuclear transport. Additionally it aligns with pathways involving protein import into the nucleus reflecting its comprehensive regulatory capacity over cellular transport mechanisms.

Mutations in MOG1 have been implicated in cardiac disorders particularly familial dilated cardiomyopathy. This condition occurs when MOG1's regulatory function on nuclear transport fails affecting heart function. In neurodegenerative diseases such as Alzheimer's altered expression of MOG1 may contribute to disease pathology by disrupting nuclear-cytoplasmic transport. The interaction between MOG1 and Ran GTPase becomes critical here as it influences overall protein distribution within cells impacting disease progression.
style
left-column

Specifications

Form

Liquid

Additional notes

ab130051 was purified using conventional chromatography techniques.

style
left-column

General info

Function

May regulate the intracellular trafficking of RAN (PubMed : 11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed : 29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed : 29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed : 18184654, PubMed : 21621375, PubMed : 23420830).

Sequence similarities

Belongs to the MOG1 family.

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

May regulate the intracellular trafficking of RAN (PubMed : 11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed : 29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed : 29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed : 18184654, PubMed : 21621375, PubMed : 23420830).
See full target information RANGRF
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB233549

Anti-Myelin oligodendrocyte glycoprotein antibody [EPR22629-310] - Oligodendrocyte Marker

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin oligodendrocyte glycoprotein antibody [EPR22629-310] - Oligodendrocyte Marker (AB233549)

  • 5
  • 3
Primary Antibodies

AB109186

Anti-Olig2 antibody [EPR2673] - Oligodendrocyte Marker

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Olig2 antibody [EPR2673] - Oligodendrocyte Marker (AB109186)

  • 5
  • 22
Proteins & Peptides

AB317871

Recombinant Human MOG Protein (His-tag)

Mass Spectrometry - Recombinant Human MOG Protein (His-tag) (AB317871)

  • 0
  • 0
Primary Antibodies

AB155279

Anti-SOX10 antibody [EPR4007]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-SOX10 antibody [EPR4007] (AB155279)

  • 4
  • 7

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com