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AB160523

Recombinant Human MPPB protein

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Recombinant Human MPPB protein is a Human Full Length protein, in the 1 to 490 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

MPPB, PMPCB, Mitochondrial-processing peptidase subunit beta, Beta-MPP, P-52

1 Images
SDS-PAGE - Recombinant Human MPPB protein (AB160523)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MPPB protein (AB160523)

ab160523 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

O75439

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as PMPCB.
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Sequence info

[{"sequence":"MAAAAARVVLSSAARRRLWGFSESLLIRGAAGRSLYFGENRLRSTQAATQVVLNVPETRVTCLESGLRVASEDSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSISRKDLVDYITTHYKGPRIVLAAAGGVSHDELLDLAKFHFGDSLCTHKGEIPALPPCKFTGSEIRVRDDKMPLAHLAIAVEAVGWAHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTDTGLWGLYMVCESSTVADMLHVVQKEWMRLCTSVTESEVARARNLLKTNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVNAETIREVCTKYIYNRSPAIAAVGKPGFFSSMQKVGQVLLINSSF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":490,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75439","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MPPB also known as multi-purpose binding protein has a mass of approximately 55 kDa. This protein is expressed in various tissues including liver brain and muscle. MPPB plays a role in binding multiple partners facilitating interactions between proteins and stabilizing complexes. The multi-functional nature of MPPB allows it to assist in a range of cellular processes by providing structural and logistical support to its binding partners.
Biological function summary

The multi-functional binding protein assists in cellular communication and intracellular transport. MPPB often forms part of a larger protein complex allowing it to regulate the assembly and disassembly of its components. It contributes to the maintenance of cellular structure and plays a role in signaling pathways by modulating interactions with signaling molecules. Due to its integral function disruptions in MPPB can lead to alterations in cellular function and organization.

Pathways

MPPB participates in key cellular pathways such as the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K) pathway. These pathways are important for cell growth survival and differentiation. MPPB interacts with proteins like RAF1 and AKT influencing their activity and thereby regulating downstream signaling events. By connecting and modulating these pathways MPPB maintains cellular homeostasis and directs cellular responses to external stimuli.

Multi-purpose binding protein involvement has been associated with cancer and neurodegenerative disorders. Abnormal expression or function of MPPB has shown links to tumor growth possibly by altering the MAPK or PI3K pathways. In neurodegenerative diseases MPPB might interact with proteins like tau impacting cellular stability and neural function. By understanding these interactions researchers can better target MPPB for potential therapeutic interventions in these conditions.
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Specifications

Form

Liquid

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General info

Function

Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable) (PubMed : 29576218). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (PubMed : 22354088).

Sequence similarities

Belongs to the peptidase M16 family.

Subcellular localisation

Mitochondrion matrix

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Product protocols

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Target data

Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable) (PubMed : 29576218). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (PubMed : 22354088).
See full target information PMPCB
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