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AB176084

Recombinant Human MPPED2 protein

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Recombinant Human MPPED2 protein is a Human Full Length protein, in the 1 to 294 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C11orf8, FAM1B, MPPED2, Metallophosphoesterase MPPED2, Fetal brain protein 239, Metallophosphoesterase domain-containing protein 2, 239FB

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SDS-PAGE - Recombinant Human MPPED2 protein (AB176084)
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Supplier Data

SDS-PAGE - Recombinant Human MPPED2 protein (AB176084)

15% SDS-PAGE analysis of ab176084 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q15777

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris-HCl buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAHGIPSQGKVTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMVDPIPYDTPKPAGHTRFVCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDWLGNLPYEYKIVIAGNHELTFDKEFMADLVKQDYYRFPSVSKLKPEDFDNVQSLLTNSIYLQDSEVTVKGFRIYGAPWTPWFNGWGFNLPRGQSLLDKWNLIPEGIDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQRRVRPKLHVFGGIHEGYGIMTDGYTTYINASTCTVSFQPTNPPIIFDLPNPQGS","proteinLength":"Full Length","predictedMolecularWeight":"35.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":294,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q15777","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The metallophosphoesterase domain-containing protein 2 (MPPED2) also known as c10orf59 has a molecular mass of approximately 32 kDa. This protein is characterized by a conserved metallophosphoesterase domain which suggests its role in catalyzing the hydrolysis of phosphomonoester bonds. MPPED2 is expressed in the brain and testis indicating potential roles in neurological and reproductive processes.
Biological function summary

Metallophosphoesterase domain proteins like MPPED2 participate in cellular signal transduction by modulating phosphate group removal. Though it is not widely recognized as part of a larger complex MPPED2's enzymatic activity may influence intracellular signaling pathways that are significant in the nervous system. Its expression patterns suggest it could have specialized roles in neurons or glial cells possibly affecting brain development or function.

Pathways

MPPED2 interacts with signaling networks related to phosphoinositide metabolism and possibly PI3K/AKT pathway. These pathways are central to cell survival growth and metabolism. MPPED2's activity could influence these processes through regulation of phosphate-related signaling intermediates. It may also interact indirectly with proteins like PTEN known for its role in tumor suppression through lipid phosphatase activity.

MPPED2 has been linked to neurodevelopmental abnormalities and cancer. Its expression is altered in some tumor cells hinting at a potential role in oncogenesis. Additionally the protein may interact with other regulatory proteins such as PTEN in a context of disease progression particularly when normal phosphatase activities are disrupted. Understanding MPPED2's exact function could lead to insights into its role in such conditions and possible therapeutic interventions.
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Specifications

Form

Liquid

Additional notes

ab176084 is purified using conventional chromatography techniques.

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General info

Function

Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.

Sequence similarities

Belongs to the UPF0046 family.

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Product protocols

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Target data

Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.
See full target information MPPED2
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