Recombinant Human MRC2/ENDO180 protein is a Human Fragment protein, in the 105 to 214 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
A S L G M Y E C D R E A L N L R W H C R T L G D Q L S L L L G A R T S N I S K P G T L E R G D Q T R S G Q W R I Y G S E E D L C A L P Y H E V Y T I Q G N S H G K P C T I P F K Y D N Q W F H G C T S T G R E D G H L W C A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes (recombinant protein) |
Target data
Function
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Alternative names
CD280, CLEC13E, ENDO180, KIAA0709, UPARAP, MRC2, C-type mannose receptor 2, C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, Urokinase receptor-associated protein
Recommended products
Recombinant Human MRC2/ENDO180 protein is a Human Fragment protein, in the 105 to 214 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- Q9UBG0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- A S L G M Y E C D R E A L N L R W H C R T L G D Q L S L L L G A R T S N I S K P G T L E R G D Q T R S G Q W R I Y G S E E D L C A L P Y H E V Y T I Q G N S H G K P C T I P F K Y D N Q W F H G C T S T G R E D G H L W C A
- Accession
- Q9UBG0
- Protein length
- Fragment
- Predicted molecular weight
- 37.73 kDa
- Amino acids
- 105 to 214
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as MRC2.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MRC2 also known as the Endo180 protein is a type 1 transmembrane receptor with a structure that includes a fibronectin type II domain eight C-type lectin domains and a cysteine-rich domain. This protein has an approximate molecular mass of 180 kDa. MRC2 is widely expressed in various human tissues with noticeable expression in fibroblasts macrophages and certain endothelial cells. The protein plays a role in endocytosis involving the binding and internalization of collagen and other extracellular matrix components.
- Biological function summary
MRC2 serves several significant roles including its involvement in tissue remodeling cellular migration and extracellular matrix turnover. The protein forms part of a larger complex involving other matrix-interacting proteins allowing for efficient capture and presentation of ligands. MRC2 contributes to the regulation of collagen homeostasis through interaction with collagenase and facilitates uptake and processing of collagen.
- Pathways
MRC2 takes part in cellular processes connected to collagen metabolism and tissue remodeling. It is particularly involved in pathways such as the receptor-mediated endocytosis pathway and collagen degradation pathway. Interactions between MRC2 and proteins like uPAR (urokinase receptor) highlight its role in plasminogen activation which is essential for extracellular matrix breakdown and cell migration.
- Associated diseases and disorders
MRC2 displays connection to tissue fibrosis and cancer metastasis. In fibrosis dysregulation of MRC2 can lead to excessive collagen deposition which contributes to disease progression. In cancer abnormal MRC2 activity associates with enhanced tumor cell invasion and metastasis. Additionally MRC2's interaction with uPAR suggests its involvement in tumor progression further emphasizing its potential as a therapeutic target for disease modulation.
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1 product image
SDS-PAGE - Recombinant Human MRC2/ENDO180 protein (ab112386)
12.5% SDS-PAGE analysis of ab112386. Stained with Coomassie Blue
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