Recombinant Human MRGX protein
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Recombinant Human MRGX protein is a Human Full Length protein, in the 1 to 288 aa range, expressed in Escherichia coli, with >95%, 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.
View Alternative Names
KIAA0026, MRGX, MORF4L2, Mortality factor 4-like protein 2, MORF-related gene X protein, Protein MSL3-2, Transcription factor-like protein MRGX
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human MRGX protein (AB172166)
SDS-PAGE gel of ab172166 under non reduced (lane 1) and reduced (lane 2) conditions.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This receptor contributes to the modulation of nociceptive signals and influences pain sensation and response. MRGX does not form part of a complex; it functions independently to modulate pain pathways by interacting with peptides and other small molecules. It also regulates calcium ion concentrations within neurons which is essential for neurotransmission and signal propagation. The interaction of MRGX with these elements highlights its significant contribution to the sensory regulatory processes.
Pathways
Research associates MRGX with pain perception and sensory transmission pathways. It intersects with the neuropeptide signaling pathway influencing proteins such as substance P and calcitonin gene-related peptide (CGRP) both key players in pain signal pathways. MRGX modulates the activity of these signaling molecules affecting how the body interprets and reacts to painful stimuli. This receptor's involvement in these pathways demonstrates its impact on the physiological responses to pain.
Specifications
Form
Lyophilized
Additional notes
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
General info
Function
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Subcellular localisation
Nucleus
Target data
Complementary Products
Primary Antibodies
AB250034
Anti-MRGX antibody [EPR9775(2)] - BSA and Azide free
RabMAb|Recombinant
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX antibody [EPR9775(2)] - BSA and Azide free (AB250034)](https://content.abcam.com/products/images/mrgx-antibody-epr97752-bsa-and-azide-free-ab250034--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img48754.jpg)
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Product promise
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