JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB165130

Recombinant Human MRGX3 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human MRGX3 protein is a Human Full Length protein, in the 1 to 322 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

MRGX3, SNSR1, SNSR2, MRGPRX3, Mas-related G-protein coupled receptor member X3, Sensory neuron-specific G-protein coupled receptor 1/2

1 Images
SDS-PAGE - Recombinant Human MRGX3 protein (AB165130)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human MRGX3 protein (AB165130)

ab165130 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q96LB0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MDSTIPVLGTELTPINGREETPCYKQTLSFTGLTCIVSLVALTGNAVVLWLLGCRMRRNAVSIYILNLVAADFLFLSGHIICSPLRLINIRHPISKILSPVMTFPYFIGLSMLSAISTERCLSILWPIWYHCRRPRYLSSVMCVLLWALSLLRSILEWMFCDFLFSGANSVWCETSDFITIAWLVFLCVVLCGSSLVLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGIQWALFSRIHLDWKVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDTPEVDEGGGWLPQETLELSGSRLEQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":322,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96LB0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MRGX3 also known as MAS-related G protein-coupled receptor member X3 is a G protein-coupled receptor primarily involved in cell signaling. It has a molecular mass of approximately 45 kDa. MRGX3 predominantly expresses in the dorsal root ganglia and a subset of sensory neurons. As a receptor MRGX3 binds to specific ligands and activates intracellular G proteins leading to downstream signaling cascades.
Biological function summary

The receptor influences pain sensation and modulation pathways. It does this by interacting with various ligands to modulate neuronal excitability. MRGX3 does not appear to form part of a larger receptor complex but acts within the framework of peripheral nervous system signaling. Its presence in sensory neurons suggests an essential role in responding to environmental stimuli and possibly modulating inflammatory responses.

Pathways

MRGX3 takes part in the pain regulation and sensory perception pathways. It interacts with other proteins like TRPV1 which is involved in the heat pain pathway and modulates pain sensation. While MRGX3's precise place in the signaling pathway is not entirely understood it is clear that it influences signal transduction through G protein-dependent mechanisms relevant for pain and sensory functions.

MRGX3 connects to neuropathic pain and chronic inflammation-related disorders. Alterations or dysregulation of MRGX3 function can contribute to exacerbated pain states. Studies suggest an interaction with proteins such as GPR183 linking MRGX3 to the development of chronic pain disorders though research is ongoing to fully elucidate these connections.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

style
left-column

Product protocols

style
left-column

Target data

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
See full target information MRGPRX3
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB165455

Recombinant Human ZNF358 protein

SDS-PAGE - Recombinant Human ZNF358 protein (AB165455)

  • 0
  • 0
Proteins & Peptides

AB165467

Recombinant Human ZBTB46 protein

SDS-PAGE - Recombinant Human ZBTB46 protein (AB165467)

  • 0
  • 0
Proteins & Peptides

AB202175

Recombinant Human UBLCP1 protein

SDS-PAGE - Recombinant Human UBLCP1 protein (AB202175)

  • 0
  • 0
Proteins & Peptides

AB165841

Recombinant Human UBR1 protein

SDS-PAGE - Recombinant Human UBR1 protein (AB165841)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com