Recombinant Human MRI protein
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Recombinant Human MRI protein is a Human Full Length protein, in the 1 to 157 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
C7orf49, MRI, CYREN, Cell cycle regulator of non-homologous end joining, Cell cycle regulator of NHEJ, Modulator of retrovirus infection homolog
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human MRI protein (AB140733)
15% SDS-PAGE analysis of ab140733 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MRI provides critical insights into the structure and function of the human body by visualizing soft tissues in great detail. This technology plays a powerful role in identifying the complex anatomy of tissues and organs giving it a significant presence in medical diagnostics. MRI can assess functional aspects of biological processes through techniques like functional MRI (fMRI) which measures brain activity by detecting changes in blood flow. Though MRI is not a biological molecule or part of any specific complex it contributes substantially to biological research by helping understand tissue composition and organ dysfunctions.
Pathways
MRI significantly impacts the study of biological processes and pathways by allowing detailed observation of real-time physiological processes. MRI is indispensable in evaluating the pathways related to neurological and cardiovascular systems. For example it aids in the visualization of neural connections and the assessment of blood vessels offering insights into the dynamic processes within these networks. Despite not being directly involved with molecular pathways MRI complements studies involving proteins such as those implicated in neural signaling or cardiac muscle contractions by enabling precise structural and functional assessments.
Specifications
Form
Liquid
Additional notes
ab140733 was purified using conventional chromatography techniques.
General info
Function
Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed : 24610814, PubMed : 28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed : 28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed : 28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (PubMed : 28959974). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle : promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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