Recombinant Human MRM1 protein (His tag N-Terminus)
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Recombinant Human MRM1 protein (His tag N-Terminus) is a Human Full Length protein, in the 21 to 353 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
16S rRNA (guanosine(1145)-2'-O)-methyltransferase, 16S rRNA [Gm1145] 2'-O-methyltransferase, MRM1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human MRM1 protein (His tag N-Terminus) (AB140719)
15% SDS-PAGE analysis of ab140719 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MRM1 acts to regulate the fidelity and efficiency of mitochondrial translation. MRM1 functions as part of a larger ribonucleoprotein complex. This complex includes several other proteins responsible for rRNA processing and modification ensuring the ribosome's structural and functional integrity. The precise modification carried out by MRM1 facilitates accurate and efficient protein synthesis which is necessary for mitochondrial function.
Pathways
The methyltransferase activity of MRM1 integrates into mitochondrial translation and energy production pathways. In these pathways MRM1 through its methylation function interacts with proteins like MRP-S5 important for forming functional mitochondrial ribosomes. This activity contributes significantly to cellular energy production as it impacts the oxidative phosphorylation pathway a central pathway for ATP generation.
Specifications
Form
Liquid
Additional notes
ab140719 is purified using conventional chromatography techniques.
General info
Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Sequence similarities
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Subcellular localisation
Mitochondrion
Target data
Complementary Products
Product promise
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